Results 81 to 90 of about 150,750 (242)
Zhongguo shiyan zhenduanxue, 2018 目的证实PS-1环状RNA(Cir-PS1-615)的存在,建立Cir-PS1-615的检测方法,并对其与AD的关系进行初步研究。方法采用反向PCR后克隆测序的方法,在人神经母细胞瘤SY5Y细胞对PS1基因的十二个外显子设计引物分别检测,发现可能存在的环状RNA,并对30例AD患者及对照组全血进行RT-qPCR检测。结果证实了PS1基因第2-5外显子有环状RNA的存在(Cir-PS1-615),对AD患者与对照组血液进行检测,发现AD患者与对照组血液Cir-PS1-615有差异表达。结论 ...
胡国艳 +6 more
doaj
Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis
British Journal of Clinical Pharmacology, EarlyView.Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Hyponatremia is a common yet potentially serious adverse event associated with antidepressants. Identifying the antidepressant class with the least risk of hyponatremia would improve patient safety. Methods Using electronic medical records from 15 hospitals standardized into Observational Medical Outcomes Partnership Common Data Model (2003–2023 ...
Kyungyeon Jung +21 more
wiley +1 more source
Liver Transplantation, EarlyView., 2022 Abstract Hepatopulmonary syndrome (HPS) is associated with increased waitlist mortality in liver transplantation (LT) candidates. Children with HPS are granted Model for End‐Stage Liver Disease (MELD)/Pediatric End‐Stage Liver Disease (PELD) exception points for waitlist prioritization in the United States based on criterion developed for adults.
Muhammad H. Raza +8 more
wiley +1 more source
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Marine silicon for biomedical sustainability
BMEMat, EarlyView.Schematic illustrating marine silicon for biomedical engineering. Abstract Despite momentous divergence from oceanic origin, human beings and marine organisms exhibit elemental homology through silicon utilization. Notably, silicon serves as a critical constituent in multiple biomedical processes.
Yahui Han +3 more
wiley +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract The objective of this work is to demonstrate that the inclusion of an up‐flow anaerobic sludge bed (UASB reactor) within an industrial wastewater treatment plant reduces the plant's investment and operating costs compared to a system based solely on conventional complete‐mix activated sludge (CMAS), operating under the same design principles ...
Juan Manuel Morgan‐Sagastume +1 more
wiley +1 more source
Use of Handgrip Strength as a Health Indicator in Public Sector Workers: A Cross-Sectional Study
Journal of Functional Morphology and KinesiologyObjectives: Handgrip strength (HGS) has been used as an important health indicator due to its ability to predict morbidity and mortality risks in various populations.
Raynann Crislayne de Souza Borges +6 more
doaj +1 more source
Strain‐based modeling and analysis for rock blasting and geomechanics applications
Deep Underground Science and Engineering, EarlyView.This paper introduces a novel strain‐based modeling approach for blasting and geomechanical applications, using measurable variables like particle velocity, strain, and displacement. By bypassing complex constitutive relations, strain‐based models capture critical blasting trends and full‐blast design parameters with minimal calibration.
Ruilin Yang
wiley +1 more source
Molten Zinc Coordination Polymer Glass as a Host for Stable and Processable Optical Dye Composites
EcoEnergy, EarlyView.Zinc‐based coordination polymer glass is employed to suppress aggregation‐caused quenching (ACQ) and enhance molecular stability, enabling improved luminescence performance in the solid state. The emission color of the hybrid composites can be tuned by varying the incorporated guest molecules, while the glass matrix effectively prevents aggregation and
Jaeho Lee +10 more
wiley +1 more source