Results 1 to 10 of about 1,047,206 (288)
Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors
Cells, 2021 Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of multiple B-cell malignancies. These agents have also been employed with success in the treatment of patients with autoimmune diseases and immune-mediated ...
Christopher J. Kirk +3 more
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miR-616-5p Promotes Invasion and Migration of Bladder Cancer via Downregulating NR2C2 Expression
Frontiers in Oncology, 2021 BackgroundMicroRNAs, small non-coding RNA molecules with about 22 nucleotides in length, play a significant role in the development of bladder cancer. Previous studies found that miR-616-5p could promote the progress of cancers.
Wenbiao Ren +13 more
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Frontiers in Immunology, 2023 Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyte activation ...
Tony Muchamuel +9 more
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Scientific Reports, 2023 The NFE2L1 transcription factor (aka Nrf1) is a basic leucine zipper protein that performs a critical role in the cellular stress response pathway. Here, we characterized a novel variant of NFE2L1 referred to as NFE2L1-616. The transcript encoding NFE2L1-
Daniel V. Ho +4 more
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Pharmaceuticals, 2023 A series of 24 new 1H-1,2,3-triazole hybrids of 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA (1)) and 11-keto-β-boswellic acid (β-KBA (2)) was designed and synthesized by employing “click” chemistry in a highly efficient manner.
Najeeb Ur Rehman +9 more
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Metabolites, 2022 Endophytic bacteria boost host plant defense and growth by producing vital compounds. In the current study, a bacterial strain was isolated from the Boswellia sacra plant and identified as Bacillus subtilis strain EP1 (accession number: MT256301) through
Muhammad Numan +4 more
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Antibiotics, 2023 In the current study, methanol (ADAM) extracts and their fractions, including chloroform (ADAC), ethyl acetate (ADAE), n-hexane (ADAH), and aqueous (ADAA) fractions, were prepared from aerial parts of Anogeissus dhofarica and evaluated for phytochemical ...
Rabia Maqsood +11 more
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Journal of Bioresources and Bioproducts, 2022 Traditionally, Laurus nobilis is used for the treatment of earaches and skin rashes as well as rheumatism. The most common technique to isolate the oil is hydro-distillation and steam-distillation.
Siham Saleh Al-Abri +4 more
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Metabolites, 2022 The current research was designed to explore the Blepharispermum hirtum Oliver (Asteraceae) stem and leaves essential oil (EO) composition extracted through hydro-distillation using gas chromatography-mass spectrometry (GC-MS) analysis for the first time.
Muddaser Shah +9 more
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