Results 171 to 180 of about 1,342,023 (338)

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

open access: yesAdvanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli   +12 more
wiley   +1 more source

Fibrillarin Contributes to the Oncogenic Characteristics of Colorectal Cancer Cells and Reduces Sensitivity to 5-Fluorouracil. [PDF]

open access: yesCancers (Basel)
Wu T   +11 more
europepmc   +1 more source

Surface Plasmon Enhanced Photoluminescence of Carbon Dots Formed In Situ on Silver Gratings

open access: yesAdvanced Science, EarlyView.
Carbon emitters formed in situ on a silver grating via plasmonic catalysis yield enhanced spontaneous emission by preferential radiative decay into surface plasmons. Enhancement manifests as emission exhibiting characteristics of coherence (polarization, directionality), and accelerated lifetimes of ∼30 ps, yielding Purcell factors of ∼70.
Maryam Sadat Amiri Naeini   +5 more
wiley   +1 more source

Reduced‐Graphene Oxide Nanofiltration Membranes Intercalated by Conjugated Polyaromatics: Towards High Monovalent Salt Rejections

open access: yesAdvanced Science, EarlyView.
We demonstrate the fabrication of a series of reduced‐GO nanofiltration membranes containing intercalated polyaromatic conjugated molecules of different structural classes. These tuned‐nanochannel membranes perform “deep nanofiltration” with remarkably high monovalent salt rejections and near‐total divalent salt rejections in a large concentration ...
Muskan Sonker, Sankar Nair
wiley   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

open access: yesAdvanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao   +11 more
wiley   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon   +21 more
wiley   +1 more source

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