Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang +5 more
wiley +1 more source
Multi-Level Transcriptomic and Physiological Responses of <i>Aconitum kusnezoffii</i> to Different Light Intensities Reveal a Moderate-Light Adaptation Strategy. [PDF]
Cao K, Mu Y, Zhang X.
europepmc +1 more source
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Healthy eating index (HEI) and stroke: Population-level clinical evidence. [PDF]
Hong J, Bita M, Lekoubou A, Ba DM.
europepmc +1 more source
Writing and artificial intelligence: <i>apprivoiser</i> one's own paper. [PDF]
Matsubara S.
europepmc +1 more source
Peptide Epitopes of NC16A BP180 in the Diagnostics of Bullous Pemphigoid. [PDF]
Lytton SD +9 more
europepmc +1 more source
Photoconductive Gain Behavior of Ni/β-Ga2O3 Schottky Barrier Diode-Based UV Detectors. [PDF]
Kopyev VV +4 more
europepmc +1 more source
Electrothermally tunable cholesteric liquid crystal laser achieving 130 nm range with high circular polarization purity (|g| ≥ 1.4). [PDF]
Jeong MY, Kwak K.
europepmc +1 more source

