Results 251 to 260 of about 1,059,062 (379)

Impact of long‐term treatment with cenobamate on concomitant usage of antiseizure medications: A real‐world retrospective study in Spain

open access: yesEpilepsia, EarlyView.
Abstract Objectives This study explored the safety and effectiveness of adjunctive cenobamate (CNB) in patients with different levels of drug‐resistant epilepsy (DRE) in a real‐world setting, including its impact on the use of co‐antiseizure medication (co‐ASM). Methods This was a single‐center, retrospective, observational study.
Juan María Sánchez‐Caro   +3 more
wiley   +1 more source

Associations between endometrial swab bacteriology and cytology findings and live foal rates in Thoroughbred broodmares in the United Kingdom

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background To date, relationships between pre‐covering endometrial swab cytology and bacteriology and fertility outcomes in Thoroughbred broodmares in the United Kingdom are unknown and could aid clinical decision making. Objectives To investigate associations between cytology and bacteriology findings from the last endometrial swab taken in ...
Billy Fehin   +4 more
wiley   +1 more source

Distribution and activity of nitrate and nitrite reductases in the microbiota of the human intestinal tract

open access: yesThe FEBS Journal, EarlyView.
Nitrate from food is first converted to nitrite by oral bacteria and then further processed in the intestine. The gut microbiota reduces nitrate and nitrite to ammonia or nitric oxide, preventing the formation of carcinogenic nitrosamines. Our analysis highlights Escherichia coli as a key player in this detoxification process, supported by other ...
Natalie Hager   +4 more
wiley   +1 more source

Patterns and predictors of change in outcome measures in clinical trials in scleroderma: an individual patient meta-analysis of 629 subjects with diffuse cutaneous systemic sclerosis.

open access: yesArthritis & Rheumatism, 2012
Peter A. Merkel   +9 more
semanticscholar   +1 more source

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

open access: yesThe FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory   +3 more
wiley   +1 more source

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