Results 141 to 150 of about 938,617 (287)

‘I, Me, Myself’: Selfhood and Melancholy in the Journals of Gertrude Savile (1697–1758)

open access: yesJournal for Eighteenth-Century Studies, EarlyView.
Abstract This article examines the journals of Gertrude Savile from 1727 in light of recent scholarship on early modern and eighteenth‐century melancholy. The concept had myriad associations with medicine, physiology, the imagination, and feeling, but questions remain about how melancholy during this period was considered by those outside the narrow ...
Daniel Beaumont
wiley   +1 more source

Real‐World Survival Outcomes in EGFR‐Mutant Advanced NSCLC Treated With EGFR TKIs: Insights From a Single‐Center Clinical Data Warehouse Analysis in South Korea

open access: yesAsia-Pacific Journal of Clinical Oncology, EarlyView.
This retrospective cohort study was conducted using clinical data derived from a single‐center clinical data warehouse (CDW). In Korean patients with EGFR‐mutant advanced NSCLC, first‐line treatment with 3G EGFR TKIs (osimertinib or lazertinib) demonstrated significantly better overall survival than 1G or 2G agents.
Bomi Kim   +3 more
wiley   +1 more source

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index

open access: yesAndrology, EarlyView.
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Richard Ivell   +3 more
wiley   +1 more source

Machine Learning for Predicting Colorectal Cancer‐Specific Mortality: The Role of Socioeconomic Inequalities in Public Policy

open access: yesANZ Journal of Surgery, EarlyView.
ABSTRACT Background Colorectal cancer remains a leading cause of mortality worldwide. We investigated whether adding socioeconomic information to machine learning models can improve the prediction of colorectal cancer‐specific mortality. Methods Using data from the Fundação Oncocentro de São Paulo (FOSP), we analyzed individuals diagnosed with ...
Felipe Mendes Delpino   +7 more
wiley   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen   +3 more
wiley   +1 more source

Safety pharmacology of acute mescaline administration in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber   +4 more
wiley   +1 more source

Sustainability in Healthcare: The Role of Digital Technologies for Improving Patient Engagement

open access: yesBusiness Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT Sustainability in healthcare is getting considerable research attention as systems worldwide tend to balance environmental, social, and economic factors. In this context, digital technologies have demonstrated significant potential to enhance engagement among different consumer groups across various industries.
Francesco Schiavone   +4 more
wiley   +1 more source

Self‐criticism and dependency in adolescents with depression: Associations with clinical features and psychological functioning

open access: yesBritish Journal of Clinical Psychology, EarlyView.
Abstract Objectives The personality dimensions of self‐criticism and dependency have been shown to confer vulnerability to depression, and psychopathology more broadly, in adults. However, evidence for the roles of these personality dimensions in young people is weaker, particularly because most studies in this area have been conducted in non‐clinical ...
Yushi Bai, Nick Midgley, Patrick Luyten
wiley   +1 more source

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