Results 131 to 140 of about 1,092 (179)

8-Aminoquinolines: Primaquine and Tafenoquine

2011
8-Aminoquinolines are an important class of antimalarial drugs because they are effective against the liver stages of Plasmodium infections and thus are administered for radical cure and presumptive antirelapse therapy against relapsing malaria. In this chapter, we discuss two 8-aminoquinolines, primaquine and tafenoquine.
Norman C. Waters, Michael D. Edstein
openaire   +1 more source

Synthesis of aminals from 8-aminoquinoline

Chemistry of Heterocyclic Compounds, 1981
The reaction of 8-aminoquinoline with substituted aromatic aldehydes leads to aminals, which are the only reaction products. The reaction with 1-formyl-2-hydroxynaphthalene proceeds with the formation of a Schiff base. The UV and mass spectra of the aminals are discussed.
N. S. Kozlov, G. V. Vorob'eva
openaire   +1 more source

Reduced 8-aminoquinoline analogues as potential antimalarial agents

Journal of Medicinal Chemistry, 1976
The synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-N,N-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-N,N-diethylaminoethyl)-6 ...
F I, Carroll, J T, Blackwell, A, Philip, C E, Twine   +3 more
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Tafenoquine: A New 8- Aminoquinoline

Medical Journal of Zambia, 2012
No ...
Prashar, L, Paul, R
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Copper-Catalyzed Regioselective C–H Sulfonylation of 8-Aminoquinolines

The Journal of Organic Chemistry, 2016
Copper(I)-catalyzed 5-sulfonation of quinolines via bidentate-chelation assistance has been developed. The reaction is compatible with a wide range of quinoline substrates and arylsulfonyl chlorides. Experimental and theoretical (DFT) investigation implicated that a single-electron-transfer process is involved in this sulfonylation transformation.
Jun, Wei, Jingxing, Jiang, Xinsheng, Xiao, Dongen, Lin, Yuanfu, Deng, Zhuofeng, Ke, Huanfeng, Jiang, Wei, Zeng   +7 more
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Antimalarial Activity of Novel 5-Aryl-8-Aminoquinoline Derivatives

Journal of Medicinal Chemistry, 2010
In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl-8-aminoquinoline derivatives was prepared and assessed for antimalarial activities.
Hiroaki, Shiraki, Michael P, Kozar, Victor, Melendez, Thomas H, Hudson, Colin, Ohrt, Alan J, Magill, Ai J, Lin   +6 more
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8-Aminoquinolines as anticoccidials-I

Bioorganic & Medicinal Chemistry Letters, 1997
Richard E. Armer, Jacqueline S. Barlow, Christopher J. Dutton, David H.J. Greenway, Sean D.W. Greenwood, Nita Lad, Ivan Tommasini   +6 more
openaire   +1 more source

Derivatives of 6-Methoxy-8-aminoquinoline and 2-Methyl-6-methoxy-8-aminoquinoline. II

Journal of the American Chemical Society, 1944
Ewald Rohrmann, H. A. Shonle
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8-Aminoquinolines

2001
Ralf P. Brueckner, Colin Ohrt, J. Kevin Baird, Wilbur K. Milhous   +3 more
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8-Aminoquinolines

1984
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