Results 71 to 80 of about 4,148,028 (340)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Growth and Development Management in Iran, An Analysis of Growth Constraints; grounded theory Approach [PDF]

پژوهش‌های مدیریت عمومی, 2019
In this research, using the HRV approach and based on the growth diagnostics decision tree, we examined the limitations of Iran's economic growth during 1380 to 1395. The research methodology is grounded theory approach and benefited from open interview.
Amin Akbarzadeh, Mosayeb Pahlavani, Seyed Hossein Mirjalili   +2 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan, María A. Piedrabuena, María A. Zarate, Sofía Rodríguez Murúa, Ezequiel I. Surace, Mauricio F. Farez, Marcela P. Fiol, María C. Ysrraelit, Jorge Correale   +8 more
wiley   +1 more source

Will the US Economy Recover in 2010? A Minimal Spanning Tree Study [PDF]

, 2010
We calculated the cross correlations between the half-hourly times series of the ten Dow Jones US economic sectors over the period February 2000 to August 2008, the two-year intervals 2002--2003, 2004--2005, 2008--2009, and also over 11 segments within ...
Andersen, Andersen, Andrews, Azad, Bai, Bai, Bai, Bai, Bai, Bai, Bai, Bai, Baker, Baker, Barberis, Barndorff-Nielsen, Baxter, Bernaola-Galván, Boginski, Bollerslev, Bonanno, Bonanno, Bonanno, Bordo, Borghesi, Brida, Brida, Brida, Camacho, Canova, Carrion-i-Silvestre, Carrion-i-Silvestre, Chalamandaris, Chauvet, Chauvet, Cheong, Cheong, Cheung, Chong, Chong, Claessens, Claessens, Coelho, Coelho, Coronnello, Croux, Dacorogna, Di Matteo, Duch, Eom, Eom, Eryiğit, Fama, Forbes, Fortunato, Gilmore, Girvan, Gladys Hui Ting Lee, Gligor, Goldfeld, Graham, Guo, Hamilton, Hansen, Heimo, Hill, Hill, Hill, Im, Jacod, Jain, Jian Cheng Wong, Johnson, Jun Liang Kok, Jung, Jung, Karolyi, Kim, Koutrouvelis, Koutrouvelis, Krawiecki, Kruskal, Kulkarni, Kullmann, Laloux, Lancichinetti, Lavielle, Li, Lin, Lo, Loader, Lumsdaine, Mamun, Manamohan Prusty, Mantegna, Mantegna, Marcellino, McCulloch, McCulloch, Miccichè, Mirestean, Miśkiewicz, Newman, Newman, Nolan, Nolan, Nolan, Nolan, Onnela, Onnela, Onnela, Onnela, Panton, Panton, Perron, Plerou, Pozzi, Prim, Reichardt, Rigobon, Román-Roldán, Schwert, Shen, Siew Ann Cheong, Simpson, Sneath, Stockman, Tamirisa, Taylor, Tola, Tudor, Tumminello, Tumminello, Tumminello, Utsugi, Vaglica, Wilcox, Wilcox, Wong, Wong, Worsdale, Yiting Zhang, Zivot, Zolotarev, Çukur   +144 more
core   +1 more source

Quantitative Shape Irregularity and Density Heterogeneity Predict Hematoma Expansion in Patients With Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study aimed to explore the association between quantitative shape irregularity and density heterogeneity of hematomas and hematoma expansion (HE) for intracerebral hemorrhage (ICH) patients. Methods This cohort study included patients arriving within 24 h of symptom onset between August 2021 and July 2022 as the derivation cohort ...
Zeqiang Ji, Yunyi Hao, Bin Gao, Xiaojing Zhang, Yani Zhang, Jiaokun Jia, Xue Xia, Yuhao Guo, Sijia Li, Jianwei Wu, Kaijiang Kang, Xingquan Zhao   +11 more
wiley   +1 more source

Benchmarking Central Ohio 2008 [PDF]

, 2008
On April 2, 2008 Benchmarking Central Ohio 2008 was released at a forum at the Columbus Metropolitan Club. The report assesses how the 8-county Columbus metropolitan area is doing, in comparison to 15 other metro areas, using a panel of 60 diverse ...

core  

Factors Affecting Health Expenditures in Islamic Countries of D-8 Group [PDF]

فصلنامه پژوهش‌های اقتصادی ایران, 2018
Given the existence of a mutual relationship between human health and economic growth in societies, determining factors influencing human health can be effective in formulating executive policies and plans.
Navid Kargardehbidi, Effat Ghorbanian, Fatemeh Fathi   +2 more
doaj   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source

The impact of foreign direct investment and financial development on economic growth from ASEAN countries period 1995-2014

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kinh tế và Quản trị kinh doanh, 2020
This paper investigates the impact of foreign direct investment (FDI) and financial development on economic growth in ASEAN countries.The paper also investigates the impactofthe interaction between FDIand financial development on economic ...
Nguyễn Minh Kiều, Nguyễn Thị Ngọc Diệp, Nguyễn Kim Nam, Nguyễn Thị Hằng Nga   +3 more
doaj