Results 111 to 120 of about 4,923,437 (352)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Monetary Policy Analysis in a Small Open Economy: A Dynamic Stochastic General Equilibrium Approach [PDF]

This paper develops and estimates a dynamic stochastic general equilibrium model of a small open economy which approximately accounts for the empirical evidence concerning the monetary transmission mechanism, as summarized by impulse response functions ...
Vitek, Francis
core   +1 more source

Attenuation of Typical Sex Differences in 800 Adults with Autism vs. 3,900 Controls

PLoS ONE, 2014
Sex differences have been reported in autistic traits and systemizing (male advantage), and empathizing (female advantage) among typically developing individuals.
S. Baron-Cohen, Sarah A. Cassidy, B. Auyeung, C. Allison, Maryam Achoukhi, Sarah Robertson, Alexa Pohl, M. Lai   +7 more
semanticscholar   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Nonsmooth Lagrangian mechanics and variational collision integrators [PDF]

, 2003
Variational techniques are used to analyze the problem of rigid-body dynamics with impacts. The theory of smooth Lagrangian mechanics is extended to a nonsmooth context appropriate for collisions, and it is shown in what sense the system is symplectic ...
Fetecau, R. C., Marsden, J. E., Ortiz, M., West, M.   +3 more
core  

Cascade and anti-Cascade Polarization Measurements at 800 GeV/c

, 2006
The polarization of neutral Cascade and anti-Cascade hyperons produced by 800 GeV/c protons on a BeO target at a fixed targeting angle of 4.8 mrad is measured by the KTeV experiment at Fermilab.
A. Alavi-Harati, A. Bellavance, A. Glazov, A. Golossanov, A. Ledovskoy, A. R. Barker, A. R. Erwin, B. Cox, B. Winstein, C. Caso, C. O. Escobar, C. Velissaris, D. A. Jensen, D. E. Smith, E. Abouzaid, E. Blucher, E. C. Swallow, E. Cheu, E. D. Zimmerman, E. J. Ramberg, E. Monnier, E. Santos, E. T. Worcester, G. J. Bock, H. B. White, H. Huang, H. Nguyen, H. Ping, J. Shields, J. Wang, J. Whitmore, K. Hanagaki, K. Heller, K. Kotera, K. S. Nelson, L. Bellantoni, M. Arenton, M. D. Corcoran, M. Ronquest, M. Wilking, M. Worcester, N. Solomey, P. A. Toale, P. Gouffon, P. L. McBride, R. A. Gomes, R. Coleman, R. E. Ray, R. F. Zukanovich, R. Ford, R. Kessler, R. Niclasen, R. Tschirhart, R. Winston, S. Bright, T. Alexopoulos, T. Rooker, T. Yamanaka, V. Prasad, W. Slater, X. R. Qi, Y. B. Hsiung, Y. W. Wah   +62 more
core   +1 more source

THE ELECTRIC RESISTANCE AND CAPACITY OF BLOOD FOR FREQUENCIES BETWEEN 800 AND 4½ MILLION CYCLES

The Journal of General Physiology, 1925
1. The variation of the experimental values (R (ω)), (C (ω)) of the resistance and capacity of blood for increasing frequencies is approximately represented by the equation: See PDF for Equation in which R o and C o are the resistance and capacity of the
H. Fricke, Sterne Morse
semanticscholar   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

An optimized multi-proxy, multi-site Antarctic ice and gas orbital chronology (AICC2012): 120--800 ka

, 2012
An accurate and coherent chronological framework is essential for the interpretation of climatic and environmental records obtained from deep polar ice cores.
L. Bazin, A. Landais, B. Lemieux-Dudon, H. T. M. Kele, D. Veres, F. Parrenin, P. Martinerie, C. Ritz, E. Capron, V. Lipenkov, M. Loutre, D. Raynaud, B. Vinther, A. Svensson, S. Rasmussen, M. Severi, T. Blunier, M. Leuenberger, H. Fischer, V. Masson‐Delmotte, J. Chappellaz, E. Wolff   +21 more
semanticscholar   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source