Results 61 to 70 of about 4,470,378 (285)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Medwaves e-Newsletter. October 2007 [PDF]

, 2007
(5 page ...

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Texture evolution in biocompatible Mg-Y-Re alloy after friction stir processing [PDF]

, 2019
The presented study deals with the investigation of biocompatible WE 43 Mg-based alloy processed via the combination of rotary swaging (RS) and friction stir processing (FSP) at three different rotational speeds of 400 RPM, 800 RPM, and 1200 RPM.
Dvořák, Jiří, Kocich, Radim, Král, Petr, Kunčická, Lenka   +3 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enhancing farm productivity, profitability, sustainability and livelihood of small farm holders through integrated farming system

The Indian Journal of Agricultural Sciences
The present study was carried out from 2018 to 2024 at ICAR-Research Complex for Eastern Region, Patna, Bihar to evaluate eight farming system models [Field crops (FC) alone; FC + Fish + Duck; FC + Fish + Poultry; FC + Fish + Cattle; FC + Fish ...
SANJEEV KUMAR, ABHISHEK KUMAR, SHIVANI, SANTOSH KUMAR, RAKESH KUMAR, RACHNA DUBEY, KUMARI SHUBHA, KIRTI SAURABH, MANIBHUSHAN, ANUP DAS   +9 more
doaj   +1 more source

Proceedings of the Lifesaving Foundation’s 2010 Research Conference & Ireland Medal Ceremony [PDF]

, 2010
The Lifesaving Foundation Ltd (2010) These Proceedings are freely available in the public domain for distribution to anyone involved and interested in decreasing drowning deaths around the world.
Avramidis, S, Stallman, RK
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Direct observation of ultrafast thermal and non-thermal lattice deformation of polycrystalline Aluminum film

, 2017
The dynamics of thermal and non-thermal lattice deformation of nanometer thick polycrystalline aluminum film has been studied by means of femtosecond (fs) time-resolved electron diffraction.
Cao, Jianming, Chen, Jie, Li, Runze, Rentzepis, Peter M., Zhang, Jie, Zhu, Pengfei   +5 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Nonsmooth Lagrangian mechanics and variational collision integrators [PDF]

, 2003
Variational techniques are used to analyze the problem of rigid-body dynamics with impacts. The theory of smooth Lagrangian mechanics is extended to a nonsmooth context appropriate for collisions, and it is shown in what sense the system is symplectic ...
Fetecau, R. C., Marsden, J. E., Ortiz, M., West, M.   +3 more
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