Results 61 to 70 of about 4,485,248 (303)

Tensiometer based irrigation scheduling in wheat (Triticum aestivum) in middle Indo-Gangetic plains

open access: yesThe Indian Journal of Agricultural Sciences, 2022
The most common method of irrigation in eastern India is through tube wells with a fixed irrigation interval, irrespective of the soil type and climatic demand resulting in over-irrigation or under-irrigation under different soil and weather situations ...
PREM K SUNDARAM   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Evaluation of the whanau carers training programme delivered by LIFE Unlimited [PDF]

open access: yes, 2004
In response to the needs of Maori informal carers, a training programme was developed for whanau carers in the Waikato region. It was delivered by LIFE Unlimited.
Ashwell, Allanah   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Genetic Relationship of Productive Life, Production and Type Traits of Korean Holsteins at Early Lactations [PDF]

open access: yesAsian-Australasian Journal of Animal Sciences, 2015
The present study was performed to study the genetic relationship of productive life with production and type traits of Korean Holsteins at first three lactations.
Nidarshani Wasana   +7 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

O papel da produção de novidades na agricultura familiar: estudo de caso de um condomínio de grãos no sudoeste do Paraná

open access: yesColóquio, 2018
O objetivo deste trabalho foi o de analisar o surgimento de novidades em torno de uma experiência familiar em um condomínio de grãos na Região Sudoeste do PR, evidenciando seus resultados para os atores sociais envolvidos.
Jhuly Caroline Biava   +2 more
doaj   +1 more source

In vitro and in vivo TNFa synthesis modulation by methylguanidine, an uremic catabolyte [PDF]

open access: yes, 1999
Original article can be found at: http://www.sciencedirect.com/science/journal/00243205 Copyright Elsevier Inc.We have investigated whether methylguanidine (MG), an uremic toxin, modulates the expression of the inducible nitric oxide synthase (iNOS) and ...
Aucella   +21 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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