Results 41 to 50 of about 50,370,645 (240)
Krugman, Carol -- 1972-90 -- Correspondence, Individual -- letter, 1978-08-30
, 1978 Letter from Krugeracha, La to Queridos dated 1978-08-30.Sabin Collection Fair Use ...
Krugeracha, La
core +1 more source
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Advanced Science, EarlyView.By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen +11 more
wiley +1 more source
Bio‐Inspired Internal Stress Engineering for Microscale Surface Cracking in Sensitive Strain Sensors
Advanced Science, EarlyView.This study presents a bio‐inspired internal stress engineering strategy to fabricate highly sensitive crack‐based strain sensors. By harnessing the internal expansion energy of microspheres and the thickness‐dependent brittle‐to‐ductile transition of ultrathin gold films, tunable microscale cracks are generated.
Jae Yeong Jang, Hanchul Cho, Young Jung
wiley +1 more source
Multi-fidelity constraints in blackbox optimization
EURO Journal on Computational OptimizationThis work studies constrained blackbox optimization problems that cannot be solved in a reasonable time due to prohibitive computational costs. This challenge is especially prevalent in industrial applications, where blackbox evaluations are costly ...
Stéphane Alarie +4 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang +9 more
wiley +1 more source
Sidney, Sylvia -- 1978-90 -- Correspondence, Individual -- letter, 1990-03-08
, 1990 Letter from Sabin, Albert B.
Sabin, Albert B. (Albert Bruce), 1906-1993
core +1 more source
Chelala, Cesar -- 1985-90 -- Correspondence, Individual -- letter, 1990-02-08
, 1990 Letter from Sabin, Albert B. to Chelala, César A.
Sabin, Albert B. (Albert Bruce), 1906-1993
core +1 more source
Analysis of day-to-day variations in air temperature in the region of Siedlce
Acta Scientiarum Polonorum. Formatio CircumiectusAim of the study: As a result of the increase in average air temperature associated with the present-day climate change, heatwaves are forecast to occur with increasing frequency.
Elżbieta Radzka +2 more
doaj +1 more source
Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
Molecules, 2020 This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e ...
Zofia Bernat +4 more
doaj +1 more source