Results 31 to 40 of about 243,587 (207)

Development of Aβ and anti-Aβ dynamics models for Alzheimer’s disease

Computational and Mathematical Biophysics
Alzheimer’s disease is one of the most prevalent types of dementia worldwide. It is caused by the accumulation of amyloid-beta (Aβ) plaques in the brain, disrupting communication pathways and memory.
Cindyawati Cindyawati, Ahmad Faozan, Hardhienata Hendradi, Kartono Agus   +3 more
doaj   +1 more source

Derivation and travelling wave analysis of phenotype-structured haptotaxis models of cancer invasion

European Journal of Applied Mathematics
We formulate haptotaxis models of cancer invasion wherein the infiltrating cancer cells can occupy a spectrum of states in phenotype space, ranging from ‘fully mesenchymal’ to ‘fully epithelial’. The more mesenchymal cells are those that display stronger
Tommaso Lorenzi, Fiona R. Macfarlane, Kevin J. Painter   +2 more
doaj   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

O DISCURSO DE CONQUISTADORES E CONQUISTADOS NAS CRÔNICAS DE ZURARA

Convergência Lusíada, 1994
Este estudo reproduz, com pequenas variações, conferência intitulada Caravelas e Cavaleiros: das Tomadas de Ceuta e Guiné, apresentada a 11/08/92 no III Congresso da ABRALIC, realizado na UFF de 10 a 12/08/92.
Maria do Amparo Tavares Maleval
doaj  

A free boundary model for transport-induced neurite growth

European Journal of Applied Mathematics
We introduce a free boundary model to study the effect of vesicle transport onto neurite growth. It consists of systems of drift-diffusion equations describing the evolution of the density of antero- and retrograde vesicles in each neurite coupled to ...
Greta Marino, Jan-Frederik Pietschmann, Max Winkler   +2 more
doaj   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors

Advanced Science, EarlyView.
A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos, Gustavo Felizardo Santos Sandes, Artur Christian Garcia da Silva, Holli‐Joi Martin, Eugene N. Muratov, Rodolpho de Campos Braga, Bruno Junior Neves   +6 more
wiley   +1 more source

SSTR4, childhood adversity, self-efficacy and suicide risk in alcoholics

Translational Neuroscience, 2017
Patients with alcohol dependence (AD) are known to develop poor social skills, to report a higher number of adverse childhood experiences (ACEs) and to attempt suicide more frequently than the general population.
Berent Dominika, Emilien Gerard, Podgórski Michał, Kusideł Ewa, Kulczycka-Wojdala Dominika, Szymańska Bożena, Macander Marian, Pawłowska Zofia   +7 more
doaj   +1 more source

Structural organization and features of the use of multi-component complex sentences in the novel «On the humble field» by Valerii Shevchuk

Вісник Харківського національного університету імені В. Н. Каразіна. Серія Філологія. Vìsnik Harkìvsʹkogo nacìonalʹnogo unìversitetu ìmenì V.N. Karazìna. Serìâ Fìlologìâ., 2023
The article is devoted to the analysis of the structure and functioning of multi-component compound sentences in Valerii Shevchuk's speech. The novel "On the Humble Field" will serve as the research material.
Iryna Babii, Nina Svystun
doaj   +1 more source