Results 31 to 40 of about 326,128 (207)

Development of Aβ and anti-Aβ dynamics models for Alzheimer’s disease

Computational and Mathematical Biophysics
Alzheimer’s disease is one of the most prevalent types of dementia worldwide. It is caused by the accumulation of amyloid-beta (Aβ) plaques in the brain, disrupting communication pathways and memory.
Cindyawati Cindyawati, Ahmad Faozan, Hardhienata Hendradi, Kartono Agus   +3 more
doaj   +1 more source

Derivation and travelling wave analysis of phenotype-structured haptotaxis models of cancer invasion

European Journal of Applied Mathematics
We formulate haptotaxis models of cancer invasion wherein the infiltrating cancer cells can occupy a spectrum of states in phenotype space, ranging from ‘fully mesenchymal’ to ‘fully epithelial’. The more mesenchymal cells are those that display stronger
Tommaso Lorenzi, Fiona R. Macfarlane, Kevin J. Painter   +2 more
doaj   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

O DISCURSO DE CONQUISTADORES E CONQUISTADOS NAS CRÔNICAS DE ZURARA

Convergência Lusíada, 1994
Este estudo reproduz, com pequenas variações, conferência intitulada Caravelas e Cavaleiros: das Tomadas de Ceuta e Guiné, apresentada a 11/08/92 no III Congresso da ABRALIC, realizado na UFF de 10 a 12/08/92.
Maria do Amparo Tavares Maleval
doaj  

A free boundary model for transport-induced neurite growth

European Journal of Applied Mathematics
We introduce a free boundary model to study the effect of vesicle transport onto neurite growth. It consists of systems of drift-diffusion equations describing the evolution of the density of antero- and retrograde vesicles in each neurite coupled to ...
Greta Marino, Jan-Frederik Pietschmann, Max Winkler   +2 more
doaj   +1 more source

Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation

Advanced Science, EarlyView.
Sleep deprivation progressively shifts human brain dynamics from near‐critical toward supercritical states, as revealed by neuronal avalanche analysis of resting‐state fMRI. These changes track subjective sleep pressure rather than vigilance lapses and show marked network heterogeneity. A circuit model suggests that reduced inhibitory efficacy provides
Dai Zhang, Liqin Zhou, Rong Wang, Yuehua Han, Zhentao Zuo, Yanghua Tian, Ke Zhou   +6 more
wiley   +1 more source

PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes

Advanced Science, EarlyView.
A plant genomic foundation model pre‐trained on 12 species enables both accurate gene prediction and de novo gene design. Through AI‐human knowledge screening, seven designed sequences showed transcriptional activity in plants, with two expressing stable proteins—demonstrating the first DNA‐RNA‐protein expression of LLM‐generated genes in plants and ...
Changhao Li, Qizhe Zhang, Hanchen Chen, Kepeng Lin, Chengfang Luo, Mengying Yang, Wei Xu, Fan Yao, Jianbing Yan, Qing‐Yong Yang, Xuehai Hu   +10 more
wiley   +1 more source

SSTR4, childhood adversity, self-efficacy and suicide risk in alcoholics

Translational Neuroscience, 2017
Patients with alcohol dependence (AD) are known to develop poor social skills, to report a higher number of adverse childhood experiences (ACEs) and to attempt suicide more frequently than the general population.
Berent Dominika, Emilien Gerard, Podgórski Michał, Kusideł Ewa, Kulczycka-Wojdala Dominika, Szymańska Bożena, Macander Marian, Pawłowska Zofia   +7 more
doaj   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source