Results 101 to 110 of about 11,372,062 (345)

CRIANÇAS E ADOLESCENTES COMO SUJEITOS DE DIREITOS: A (IN) CONSTITUCIONALIDADE E A (IN) EFICÁCIA DA REDUÇÃO DA MAIORIDADE PENAL SOB A ÓTICA DA CONSTITUIÇÃO DA REPÚBLICA FEDERATIVA DO BRASIL DE 1988

, 2017
. Alterada pela EC No 99/17 . Alterada pela EC No 98/17 . Alterada pela EC No 97/17 . Alterada pela EC No 96/17 . Alterada pela EC No 91/17 . Alterada pela EC No 95/16 . Alterada pela EC No 94/16 . Alterada pela EC No 93/16 .
Victor Hugo Melo, E. M. D. Melo
semanticscholar   +1 more source

Toimetulekupiirangud Eesti täisealises rahvastikus – levimus ja tegelik abistamine [PDF]

, 2008
Rahvastiku vananemine on arenenud riikides muutmas toimetulekupiirangud igapäevategevuses suurimaks tervisega seotud koormaks ühiskonnas. Eesti pere- ja sündimusuuringu II etapi (Euroopa pere- ja sündimusuuringu rahvuslik osaprojekt, 7855 vastanut ...
Altmets, Katre, Katus, Kalev, Puur, Allan, Saava, Astrid, Uusküla, Anneli   +4 more
core   +2 more sources

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

A Utility-Based Rate Allocation of M2M Service in Heterogeneous Wireless Environments

International Journal of Distributed Sensor Networks, 2013
This paper presents a dynamic adaptive machine-to-machine (M2M) service rate allocation scheme for optimum traffic distribution in heterogeneous wireless environments (HWEs). According to the M2M service characteristics, it proposes the utility function,
Yao Huang, Hui Tian, Jie Zhang, Cheng Qin, Zhibo Wang   +4 more
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Agrarumweltprogramm mit Ökobilanz im Allgäu zielorientiert gestalten [PDF]

, 2000
Mit einer Ökobilanz von 18 Grünlandbetrieben in den drei relevanten Förderprogrammen des Bayerischen Kulturlandschaftsprogramms „Intensiv” - quasi ohne Auflagen, „Extensiviert” - Verbot mineralischer Stickstoffdüngung - und „Ökologischer Landbau” wurden ...
Haas, Guido
core  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Predicting COVID-19 outbreak in India using modified SIRD model

Applied Mathematics in Science and Engineering
In this paper, the existing Susceptible-Infected-Recovered-Deceased (SIRD) compartmental epidemiologic process model is modified for forecasting the coronavirus effect in India.
Sakshi Shringi, Harish Sharma, Pushpa Narayan Rathie, Jagdish Chand Bansal, Atulya Nagar, Daya Lal Suthar   +5 more
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Investigating the impact of vaccine hesitancy on an emerging infectious disease: a mathematical and numerical analysis

Journal of Biological Dynamics
Throughout the last two centuries, vaccines have been helpful in mitigating numerous epidemic diseases. However, vaccine hesitancy has been identified as a substantial obstacle in healthcare management.
Indunil M. Hewage, Kevin E. M. Church, Elissa J. Schwartz   +2 more
doaj   +1 more source