Results 91 to 100 of about 324,475 (219)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Selective Random CDD Enhanced Joint Cooperative Relay and HARQ for Delay-Tolerant Vehicular Communications

International Journal of Distributed Sensor Networks, 2015
We propose a selective random cyclic-delay diversity (CDD) enhanced joint cooperative relay and hybrid automatic repeat request (HARQ) scheme for two-hop vehicular communications.
Gang Wu, Qinghe Du, Kun Hua
doaj   +1 more source

Plant Species Recognition Using Triangle-Distance Representation

IEEE Access, 2019
Plant species recognition using leaf images is a highly important and challenging issue in botany and pattern recognition. A center problem of this task is how to accurately extract leaf image characteristics and quickly calculate the similarity between ...
Chengzhuan Yang, Hui Wei
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A DeepSHAP-Based Adversarial Attack on Machine Learning-Based Network Intrusion Detection

IEEE Access
We propose an adversarial attack for machine-learning-based network intrusion detection systems that selectively alters only the most influential features.
Byung Chang Chung, Gyu-Bum Han
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Synthesis of discrete–continuous quantum circuits with multimodal diffusion models

Machine Learning: Science and Technology
Efficiently compiling quantum operations remains a major bottleneck in scaling quantum computing. Today’s state-of-the-art methods achieve low compilation error by combining search algorithms with gradient-based parameter optimization, but they incur ...
Florian Fürrutter, Zohim Chandani, Ikko Hamamura, Hans J Briegel, Gorka Muñoz-Gil   +4 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Active noise control algorithm based on a neural network and nonlinear input-output system identification model

Archives of Acoustics, 2013
The development of digital signal processors and the increase in their computing capabilities bring opportunities to employ algorithms with multiple variable parameters in active noise control systems.
Tomasz KRUKOWICZ
doaj