Results 81 to 90 of about 2,284,230 (264)
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
This paper presents a novel LCC primary compensation + series–series (S–S) secondary compensation multi-stage compensation topology to meet the requirement for self-adaptive switching between constant current (CC) and constant voltage (CV) modes in low ...
Yu Xie +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Radio Frequency Wireless Power Transfer (RFWPT) systems operating at higher frequencies such as 6.78 MHz are drawing a lot of attention due to their advantages such as the improved user convenience, the compact size and the light weight.
Manh Tuan Tran, Woojin Choi
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Why the Kemeny Time is a constant
We present a new fundamental intuition forwhy the Kemeny feature of a Markov chain is a constant. This new perspective has interesting further implications.
Gustafson Karl, Hunter Jeffrey J.
doaj +1 more source
The big constant out, the small constant in
Some time ago, Tseytlin has made an original and unusual proposal for an action that eliminates an arbitrary cosmological constant. The form of the proposed action, however, is strongly modified by gravity loop effects, ruining its benefit. Here I discuss an embedding of Tseytlin's action into a broader context, that enables to control the loop effects.
openaire +4 more sources
For an additively written finite abelian group \(G\) Davenport's constant \(D(G)\) is defined as the maximal length \(d\) of a sequence \((g_ 1,\dots,g_ d)\) in \(G\) such that \(g_ 1+\dots +g_ d=0\), but no finite subsum equals zero. If \(C_ n=\mathbb{Z}/n\mathbb{Z}\) and \(G=C_{n_ 1}\oplus\dots\oplus C_{n_ r}\), where \(1M(G)\).
Alfred Geroldinger +1 more
openaire +2 more sources
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source

