Results 111 to 120 of about 1,226,263 (282)

Mapping MAGE-A4 expression in solid cancers for targeted therapies

Frontiers in Oncology
Melanoma-associated antigen A4 (MAGE-A4) is a promising target for anticancer therapy. However, limited contemporary data are available on the details of MAGE-A4 protein expression in different cancer types.
Christin Habigt, Sylvie Rottey, Iben Spanggaard, Juanita S. Lopez, Elena Garralda, Emiliano Calvo, Oliver Bechter, Oliver Bechter, Jayesh Desai, Rachel Galot, Leena Gandhi, Florian Heil, Natascha Rieder, Ivan Dimitrov, Iris Martinez Quetglas, Christian Heichinger, Nino Keshelava, Andreas Roller   +17 more
doaj   +1 more source

Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury

Mediators of Inflammation, 2019
Our previous studies verified the potent anti-inflammatory effects against severe acute pancreatitis (SAP) of AT-Lipoxin A4 and their analogues. However, the anti-inflammatory effects of AT-Lipoxin A4 on SAP-associated lung injury are not thoroughly ...
Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou   +7 more
doaj   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Structure Constant of the Yang-Lee Edge Singularity

, 2008
This paper studies the Yang-Lee singularity of the 2-dimensional Ising model on the cylinder via transfer matrix and finite-size scaling techniques.
JOHN F. McCABE, Nightingale M. P., TOMASZ WYDRO   +2 more
core   +2 more sources

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Impact of grain evolution on the chemical structure of protoplanetary disks

, 2010
We study the impact of dust evolution in a protoplanetary disk around a T Tauri star on the disk chemical composition. For the first time we utilize a comprehensive model of dust evolution which includes growth, fragmentation and sedimentation.
A. I. Vasyunin, Acke, Aikawa, Andrews, Ayres, Bergin, Bouwman, C. P. Dullemond, Ciesla, Cortes, D'Alessio, D'Alessio, D. S. Wiebe, Dutrey, Garrod, Glassgold, Gorti, Graham, Haisch, Hayashi, Henning, Henning, Herczeg, Hernández, Kessler-Silacci, Lee, Natta, Oliveira, Pascucci, Podosek, Qi, S. Zhukovska, Salyk, Sano, Schmitt, Semenov, Shakura, Sicilia-Aguilar, Sicilia-Aguilar, T. Birnstiel, T. Henning, Terada, Thalmann, Thrane, Umebayashi, Vasyunin, Vasyunin, Weingartner, Wilner, Öberg   +49 more
core   +1 more source

Mitochondrial CircRNA CircMT‐RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

Advanced Science, EarlyView.
CircMT‐RNR2 promotes wound healing by enhancing fibroblast proliferation, migration, contraction, and extracellular matrix (ECM) production. It sustains mitochondrial redox balance by stabilizing the antioxidant protein PRDX3, thereby reducing ROS‐induced damage. In diabetic foot ulcers, hypoxia, hyperglycemia, and reduced FGF2 and EGF expression lower
Guanglin Niu, Jennifer Geara, Yongjian Chen, Lihua Luo, Yanwei Xiao, Zhuang Liu, Margaux Gaborieau, Ling Pan, Edmund Loh, Dongqing Li, Pehr Sommar, Aoxue Wang, Xiaowei Zheng, Ning Xu Landén   +13 more
wiley   +1 more source

Ultraviolet Completion of Flavour Models

, 2010
Effective Flavour Models do not address questions related to the nature of the fundamental renormalisable theory at high energies. We study the ultraviolet completion of Flavour Models, which in general has the advantage of improving the predictivity of ...
C Hagedorn, CD Froggatt, D Aristizabal Sierra, E Bertuzzo, E Ma, F Feruglio, F Feruglio, F Feruglio, G Altarelli, G Altarelli, G Altarelli, G Altarelli, GG Ross, GL Fogli, I Medeiros Varzielas de, Ivo de Medeiros Varzielas, JF Cornwell, KS Babu, Luca Merlo, M Hamermesh, MC Gonzalez-Garcia, PF Harrison, SF King, SF King, T Schwetz, Y Lin, Z-z Xing   +26 more
core   +1 more source

From Pores to Pavement: Advanced Modeling of Aluminosilicates for Scalable Carbon Capture in Concrete

Advanced Science, EarlyView.
This study presents a transferable modeling framework for carbon capture using aluminosilicates, integrating Universal Isotherm Modeling with experimental data. It reveals how ultramicropores, alumina content, and amine functionalization influence CO2 adsorption energetics.
Pooja Anil Kumar Nair, Jéssica de O. N. Ribeiro, Murilo Daniel de Mello Innocentini, Kevin Paine, Juliana Calabria‐Holley   +4 more
wiley   +1 more source

Multi‐Scale Structural Effects of External Electrical Fields of Melt Tracks in Laser Powder Bed Fusion

Advanced Science, EarlyView.
Laser material processing is a promising technique for fabricating metal structures. Here, external electric field (EFs) assisted laser processing of metallic powders are investigated. EFs affect the melt tracks through changes in their stability and influence the grain structure in conjunction with laser intensity distribution methods. The EF‐assisted
Ankit Das, Shuichiro Hayashi, Craig B. Arnold   +2 more
wiley   +1 more source