Results 171 to 180 of about 166,195 (196)

ALOX5-Mediated LTA4 Production Enhances PLCG2/IP3 Signaling and Exacerbates Calcification in Human Aortic Valve Interstitial Cells. [PDF]

Acta Cardiol Sin
Liu S, Chen K, Jia G, Hou W, Liu J, Zhang F.   +5 more
europepmc   +1 more source

Neuroprotection after transient middle cerebral artery occlusion in male rats using kojic acid nanostructured lipid carriers: A behavioral, biochemical, and histological study on hippocampal CA1 region

Animal Models and Experimental Medicine, EarlyView.
This study demonstrates that kojic acid–loaded nanostructured lipid carriers (KA‐NLC) provide significant neuroprotection in a male rat model of middle cerebral artery occlusion (MCAO)–induced stroke. Treatment with KA‐NLCs reduced cerebral edema, improved motor and coordination balance and neurological scores, and enhanced spatial and avoidance memory.
Mobina Gheibi, Erfan Ghadirzadeh, Javid Tebyani, Seyedeh Mohadeseh Moyaedi, Khadijeh Khezri, Majid Saeedi, Ali Siahposht‐Khachaki, Narges Karimi, Melika Pourhossein, Shiva Shadi, Sasan Shafiei, Atena Sharifi‐Razavi   +11 more
wiley   +1 more source

pH‐Driven Two‐Stage Conformational Switching Activates an Acid‐Responsive Chaperone

Angewandte Chemie, EarlyView.
AchC is an ATP‐independent, pH‐responsive chaperone. AchC functions as a molecular switch, sensing pH changes and undergoing a two‐stage conformational transition: C‐terminal extension (colored in yellow) loosening at mild pH 4.0–5.5 and monomerization at strong acidic pH 3.0.
Soojeong Ham, Yeon‐Ju Jung, Hyunhee Kim, Sun‐Shin Cha, Changhan Lee   +4 more
wiley   +2 more sources

SMAD4-BPIFA1 Axis Governs Airway Antiviral Defense in Myhre Syndrome. [PDF]

Biomolecules
Di YP, Wen B, Li F, Tang F, Shen D, Lindsay ME, Lin AE, Chen Y, Mou H.   +8 more
europepmc   +1 more source

Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid‐Positive Individuals

Annals of Neurology, EarlyView.
Objective Identification of cerebral amyloid angiopathy (CAA) before its hemorrhagic manifestations remains limited. We aimed to determine whether severe enlarged perivascular spaces in the centrum semiovale (EPVS‐CSO) identify a prehemorrhagic stage of sporadic CAA by predicting the first appearance of CAA‐related hemorrhagic lesions or incident ...
Baris Alten, Elif Gokcal, Reisa A. Sperling, Zahra Shirzadi, Jasmeer P. Chhatwal, M. Edip Gurol, Scott E. Kasner, Steven M. Greenberg, Brett L. Cucchiara   +8 more
wiley   +1 more source

Maintenance of approach velocity despite increasing internal load during repeated pole vault attempts. [PDF]

Sci Rep
Kalkan H, Akbaş S, Pelvan SO, Çotuk HB, Al-Jumaili S, Duru AD, Branco F, Pires IM.   +7 more
europepmc   +1 more source

HGA-Induced Oxidative Stress Impairs Autophagy via Lysosomal Dysfunction in Alkaptonuria. [PDF]

Antioxidants (Basel)
Mastroeni P, Trezza A, Visibelli A, Geminiani M, Santucci A.   +4 more
europepmc   +1 more source