Results 71 to 80 of about 166,195 (196)

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

$$A_4$$ A4 realization of linear seesaw and neutrino phenomenology

European Physical Journal C: Particles and Fields, 2018
Motivated by the crucial role played by the discrete flavor symmetry groups in explaining the observed neutrino oscillation data, we consider the $$A_4$$ A4 realization of linear seesaw by extending the standard model (SM) particle content with two types
M. Sruthilaya, Rukmani Mohanta, Sudhanwa Patra   +2 more
doaj   +1 more source

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Mapping MAGE-A4 expression in solid cancers for targeted therapies

Frontiers in Oncology
Melanoma-associated antigen A4 (MAGE-A4) is a promising target for anticancer therapy. However, limited contemporary data are available on the details of MAGE-A4 protein expression in different cancer types.
Christin Habigt, Sylvie Rottey, Iben Spanggaard, Juanita S. Lopez, Elena Garralda, Emiliano Calvo, Oliver Bechter, Oliver Bechter, Jayesh Desai, Rachel Galot, Leena Gandhi, Florian Heil, Natascha Rieder, Ivan Dimitrov, Iris Martinez Quetglas, Christian Heichinger, Nino Keshelava, Andreas Roller   +17 more
doaj   +1 more source

Red Blood Cells as Endogenous Biotweezers for Optical Micromanipulation In Vivo

Advanced Science, EarlyView.
By synergistically integrating the long‐distance manipulation fiber probe (LDMFP) and endogenous red blood cells (RBCs) as biocompatible optical elements, a natural RBC biotweezer was developed for the desired microparticle manipulation and immune cell activation within living vasculature, which might offer an alternative tool for intravital optical ...
Tong Yang, Xinyu Ren, Dalin Ma, Hao Pang, Wei Chen, Kaize Cai, Mei Yuan, Bingzhi Zhang, Zufang Lin, Xiaoshuai Liu   +9 more
wiley   +1 more source

Towards a Comprehensive Framework for Made-to-Measure Alginate Scaffolds for Tissue Engineering Using Numerical Simulation

Gels
Alginate hydrogels are integral to many cell-based models in tissue engineering and regenerative medicine. As a natural biomaterial, the properties of alginates can vary and be widely adjusted through the gelation process, making them versatile additives
Alexander Bäumchen, Johnn Majd Balsters, Beate-Sophie Nenninger, Stefan Diebels, Heiko Zimmermann, Michael Roland, Michael M. Gepp   +6 more
doaj   +1 more source

Scalable Crackle‐Lithography for Multifunctional Enclosed Plastic Nanofluidic Devices

Advanced Science, EarlyView.
Crackle‐lithography enables scalable fabrication of enclosed plastic‐substrate‐based nanofluidic devices with interconnected nanochannels that enable molecular transport, optical interrogation, confined electroless copper deposition, and ionic memristive behavior.
Tirumala Rao Dumpala, S. Kiruthika, Siddhi Vinayak Pandey, Junyang Zhang, Solleti Goutham, Marcos Vinicius Surmani Martins, Harry Whittingham, Boya Radha, Ashok Keerthi   +8 more
wiley   +1 more source

Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury

Mediators of Inflammation, 2019
Our previous studies verified the potent anti-inflammatory effects against severe acute pancreatitis (SAP) of AT-Lipoxin A4 and their analogues. However, the anti-inflammatory effects of AT-Lipoxin A4 on SAP-associated lung injury are not thoroughly ...
Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou   +7 more
doaj   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source