Results 151 to 160 of about 114,928,473 (245)

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement. [PDF]

Chem Biol Drug Des
Paul S, Dubey S, Tiwari P.
europepmc   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development. [PDF]

FASEB J
Kumar R, Dasgupta P, Ray S, Paul S.
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

ENaC phosphorylation facilitates ankyrin-3 interaction critical for renal sodium balance. [PDF]

PNAS Nexus
Abd El-Aziz TM, Soares AG, Mironova E, Archer CR, Setouhi A, Singh BB, Stockand JD.   +6 more
europepmc   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Novel "C-Clamp" Design of Highly Selective Small-Molecule Sensors for Kinase Proteins. [PDF]

Chem Biomed Imaging
Ahmad S, Barashkin AA, Jadidi H, Calderon A, Amadou H, Ornberg AB, Nesterov EE, Nesterova IV.   +7 more
europepmc   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport [PDF]

, 1994
Korndörfer, Andrea, E A Dearey, W Bandlow, G Müller, Bandlow, Wolfhard, Dearey, Elisabeth Ann, A Korndörfer, Müller, Günter   +7 more
core   +1 more source

Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis. [PDF]

PLoS Pathog
Labruyère E, Treport T, Olivo-Marin JC, Guillen N.   +3 more
europepmc   +1 more source