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Illuminating compartmentalized AMPK signaling in single cells. [PDF]
Biochem JJhawar A, Parks K, Schmitt DL.
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Key role of the endothelium in lung ischemia-reperfusion injury: What the clinician needs to know. [PDF]
JHLT OpenBesnier E +3 more
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Pathogenicity and virulence of the blast fungus <i>Magnaporthe oryzae</i>. [PDF]
VirulenceMolinari C, Talbot NJ.
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The Intestinal Barrier: A Multilayered Gatekeeper Against Systemic Disease. [PDF]
Int J MicrobiolWakabayashi J, Kimura K, Kawauchi T.
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A-kinase anchoring proteins: protein kinase A and beyond
Current Opinion in Cell Biology, 2000Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs).
A S, Edwards, J D, Scott
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The macromolecular state of A‐kinase anchoring protein
Journal of Molecular Recognition, 2011The amendment of the interpretation of recently published size‐exclusion chromatography (SEC) data for A‐kinase anchoring protein (AKAP12) on Sephacryl‐S400 has led to an increase in the estimated size of the supermolecular state from 840 to at least 6000 kDa.
Patel, Trushar R., Winzor, Donald J.
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A-kinase anchoring protein targeting of protein kinase A in the heart
Journal of Molecular and Cellular Cardiology, 2004There is increasing evidence that subcellular targeting of signaling molecules is an important means of regulating the protein kinase A (PKA) pathway. Subcellular organization of the signaling molecules in the PKA pathway insures that a signal initiated at the receptor level is transferred efficiently to a PKA substrate eliciting some cellular response.
Mary L, Ruehr +2 more
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A-kinase anchor proteins in endocrine systems and reproduction
Trends in Endocrinology and Metabolism, 2001Over the past few years, significant progress has been made in characterizing the expression and localization of proteins that act as scaffolds for cAMP-dependent protein kinase (PK-A). These A-kinase anchor proteins (AKAPs) tether PK-A to intracellular organelles and structures, sequestering the kinase near its physiological substrates.
Stuart B Moss, George L Gerton, S B Moss
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Mechanisms of Protein Kinase A Anchoring
2010The second messenger cyclic adenosine monophosphate (cAMP), which is produced by adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect mainly through the cAMP-dependent serine/threonine protein kinase A (PKA). Due to the ubiquitous nature of the cAMP/PKA system, PKA signaling pathways underlie strict spatial and ...
Philipp, Skroblin +4 more
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Kinase-anchoring proteins in ciliary signal transduction
Biochemical Journal, 2021Historically, the diffusion of chemical signals through the cell was thought to occur within a cytoplasmic soup bounded by the plasma membrane. This theory was predicated on the notion that all regulatory enzymes are soluble and moved with a Brownian motion. Although enzyme compartmentalization was initially rebuffed by biochemists as a ‘last refuge of
Janani Gopalan +2 more
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