Results 101 to 110 of about 3,685,182 (335)

CoGeNT: A Search for Low-Mass Dark Matter using p-type Point Contact Germanium Detectors

open access: yes, 2013
CoGeNT employs p-type point-contact (PPC) germanium detectors to search for Weakly Interacting Massive Particles (WIMPs). By virtue of its low energy threshold and ability to reject surface backgrounds, this type of device allows an emphasis on low-mass ...
A. Knecht   +15 more
core   +1 more source

First Sagittarius A* Event Horizon Telescope Results. VII. Polarization of the Ring

open access: yesAstrophysical Journal Letters
The Event Horizon Telescope observed the horizon-scale synchrotron emission region around the Galactic center supermassive black hole, Sagittarius A* (Sgr A*), in 2017. These observations revealed a bright, thick ring morphology with a diameter of 51.8 ±
The Event Horizon Telescope Collaboration   +285 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Study of neutrino oscillation parameters at the INO-ICAL detector using event-by-event reconstruction

open access: yesEuropean Physical Journal C: Particles and Fields, 2019
We present the reach of the proposed INO-ICAL in measuring the atmospheric-neutrino-oscillation parameters $$\theta _{23}$$ θ23 and $$\varDelta m^2_{32}$$ Δm322 using full event-by-event reconstruction for the first time.
Karaparambil Rajan Rebin   +3 more
doaj   +1 more source

Soft QCD Measurements at LHCb

open access: yes, 2014
Studies in the forward region of charged particle multiplicity and density, as well as energy flow, are presented. These measurements are performed using data from proton-proton collisions at a center-of-mass energy of 7 TeV, collected with the LHCb ...
Ilten, Philip
core  

Follow the Mass—A Concordance Picture of Tidal Disruption Events

open access: yesThe Astrophysical Journal
Abstract Three recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics. In typical TDEs, after the star is disrupted by a supermassive black hole, the bound portion of the stellar debris follows highly eccentric trajectories ...
Julian Krolik, Tsvi Piran, Taeho Ryu
openaire   +4 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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