Results 191 to 200 of about 2,225,423 (269)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A New Species of Chrysopa

Psyche: A Journal of Entomology, 1931
Nathan Banks
doaj   +1 more source

The operculate micro land snails from the Alycaeinae (Caenogastropoda, Cyclophoridae) in Laos, with description of new species. [PDF]

Zookeys
Jirapatrasilp P, Inkhavilay K, Somvongsa C, Malavong B, Janjai T, Jeratthitikul E, Likhitrakarn N, Srisonchai R, Sutcharit C.   +8 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

<i>Elsholtzia yajiangensis</i> (Lamiaceae), a New Species From Sichuan, China. [PDF]

Ecol Evol
Liu LJ, Wang Y, Zheng HL, Luo Y, Jiang H, Wang Q.   +5 more
europepmc   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

A New Species of Stenobothrus From Connecticut, With Remarks on Other New England Species

Psyche: A Journal of Entomology, 1893
A. P. Morse
doaj   +1 more source

A New Species of Eucnemidae (Coleoptera: Elateroidea) with Its Complete Mitogenome and Mitogenome-Based Phylogenetic Analysis. [PDF]

Biology (Basel)
Meng Z, Muona J, Ruan Y, Chen Q, Chen X, Chen Q.   +5 more
europepmc   +1 more source

A New Species of Criorhina From New England

Psyche: A Journal of Entomology, 1917
Charles W. Johnson
doaj   +1 more source

Morphology and multigene phylogeny reveal a new species of Kuehneromyces from Xizang, China. [PDF]

BMC Microbiol
Zhang AQ, Liu YX, Sun HJ, Tarafder E, Chen HL, Xu JZ.   +5 more
europepmc   +1 more source