Results 61 to 70 of about 2,225,423 (269)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
A NEW TROPICAL SPECIES OF TRIPOSPORIUM
Reinwardtia, 2014 An illustrated description of Triposporium novoguineensei Rifai sp. nov. is presented based on a specimen collected at Garaina, New Guinea.A special visitor award from the Australian Government enabled me to attend the 42nd Australian and New Zealand ...
Mien A. Rifai
doaj
Acta Palaeobotanica, 2019 Palynological study of two Paleogene core sections from the Voronezh and Rostov regions (SW Russia) and one outcrop in Ukraine revealed the presence of a new Late Paleocene–Eocene species, Carpatella rossica sp. nov.
ALINA I. IAKOVLEVA
doaj +1 more source
A NEW SPECIES OF ANCYLOXYPHA [PDF]
The Canadian Entomologist, 1897 Female.—Expanse I inch. Fore wings with the costa more straight from the shoulder to near the apex than in Numitor, in this respect approaching Thymelicus; apex rounded, but less than in Numitor; outer margin and hind wing rounded, much as in Numitor; antennæ reaching but little more than one-third the distance to apex of fore wings; palpi as in ...
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A NEW BORNEAN SPECIES OF CINNAMOMUM SCH.
Reinwardtia, 2014 Arbor ramulis strictis perdense minutissime griseo tomentellis foliis oppositis coriaceis ellipticis acuminatis basi aeutis supra laevia glabra nervo mediano cum nerviis basalibus (acumine attingentibus) filiformis prominulis subtus dense subadpresse ...
a. j. g. h. kostermans
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source