On the Nature of Physiologically-Based Pharmacokinetic Models -A Priori or A Posteriori? Mechanistic or Empirical? [PDF]
Pharm Res, 2017 Korzekwa K, Nagar S.
europepmc +1 more source
Coulomb branch algebras via symplectic cohomology
Journal of Topology, Volume 19, Issue 2, June 2026.Abstract Let (M¯,ω)$(\bar{M}, \omega)$ be a compact symplectic manifold with convex boundary and c1(TM¯)=0$c_1(T\bar{M})=0$. Suppose that (M¯,ω)$(\bar{M}, \omega)$ is equipped with a convex Hamiltonian G$G$‐action for some connected, compact Lie group G$G$.
Eduardo González +2 more
wiley +1 more source
Enhancing the potency of in vivo lentiviral vector mediated gene therapy to hepatocytes
Nature CommunicationsIn vivo gene therapy to the liver using lentiviral vectors (LV) may represent a one-and-done therapeutic approach for monogenic diseases. Increasing LV gene therapy potency is crucial for reducing the effective doses, thus alleviating dose-dependent ...
Cesare Canepari +15 more
doaj +1 more source
Degree theory for 4‐dimensional asymptotically conical gradient expanding solitons
Communications on Pure and Applied Mathematics, Volume 79, Issue 5, Page 1151-1298, May 2026.Abstract We develop a new degree theory for 4‐dimensional, asymptotically conical gradient expanding solitons. Our theory implies the existence of gradient expanding solitons that are asymptotic to any given cone over S3$S^3$ with non‐negative scalar curvature. We also obtain a similar existence result for cones whose link is diffeomorphic to S3/Γ$S^3/\
Richard H. Bamler, Eric Chen
wiley +1 more source
How do ecologists estimate occupancy in practice?
Ecography, Volume 2026, Issue 5, May 2026.Over 20 years ago, ecologists were introduced to the site occupancy model (SOM) for estimating occupancy rates from detection‐nondetection data. In the ensuing decades, the SOM and its hierarchical modeling extensions have become mainstays of quantitative ecology, and estimating occupancy rates has become one of the most common applications of ...
Benjamin R. Goldstein +9 more
wiley +1 more source
Liver International, Volume 46, Issue 5, May 2026.ABSTRACT Background and Aims Hyperferritinemia encompasses heterogeneous genetic etiologies beyond HFE‐related hemochromatosis. Current guidelines recommend testing for rare hemochromatosis genes, yet no consensus exists on comprehensive genomic approaches.
Paul Morel +11 more
wiley +1 more source
A priori and a posteriori dietary patterns at the age of 1 year and body composition at the age of 6 years: the Generation R Study. [PDF]
Eur J Epidemiol, 2016 Voortman T +7 more
europepmc +1 more source
Fault Kinematic Controls on the Spatio‐Temporal Proximity of the 2023 Mw 7.8‐7.7 Türkiye Earthquakes
Geophysical Research Letters, Volume 53, Issue 8, 28 April 2026.Abstract The mechanism governing the spatio‐temporal proximity of the 2023 Mw 7.8‐7.7 Türkiye earthquakes remains enigmatic. Here, we used dense geodetic observations integrated with dual‐fault screw dislocation, Euler‐vector‐constrained block, and strain‐rate models to investigate the interseismic kinematics and pre‐stress state of the East Anatolian ...
Wenbin Xu +5 more
wiley +1 more source
A Priori and a Posteriori Dietary Patterns during Pregnancy and Gestational Weight Gain: The Generation R Study. [PDF]
Nutrients, 2015 Tielemans MJ +7 more
europepmc +1 more source
Revista de Métodos Cuantitativos para la Economía y la Empresa, 2019 Fue en los noventas cuando se definió el concepto de Riesgo Operacional, desde entonces las instituciones, sobre todo del sector financiero, están preocupadas en este tipo de riesgo dado que su exposición podría tener consecuencias fatales.
Dávila Aragón, Griselda +1 more
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