Results 91 to 100 of about 471,184 (284)

Hybrid Localized Spectral Decomposition for multiscale problems

, 2017
We consider a finite element method for elliptic equation with heterogeneous and possibly high-contrast coefficients based on primal hybrid formulation.
Madureira, Alexandre L., Sarkis, Marcus
core  

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

A Mollification Regularization Method for the Inverse Source Problem for a Time Fractional Diffusion Equation

Mathematics, 2019
We consider a time-fractional diffusion equation for an inverse problem to determine an unknown source term, whereby the input data is obtained at a certain time. In general, the inverse problems are ill-posed in the sense of Hadamard. Therefore, in this
Le Dinh Long, Yong Zhou, Tran Thanh Binh, Nguyen Can   +3 more
doaj   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

MAP Estimation of Chin and Cheek Contours in Video Sequences

EURASIP Journal on Advances in Signal Processing, 2004
An algorithm for the estimation of chin and cheek contours in video sequences is proposed. This algorithm exploits a priori knowledge about shape and position of chin and cheek contours in images.
Kampmann Markus
doaj   +1 more source

The heterogeneous multiscale finite element method for advection-diffusion problems with rapidly oscillating coefficients and large expected drift

Networks and Heterogeneous Media, 2010
This contribution is concerned with the formulation of a heterogeneous multiscale finite elements method (HMM) for solving linear advection-diffusion problems with rapidly oscillating coefficient functions and a large expected drift. We show that, in the
Patrick Henning, Mario Ohlberger
doaj   +1 more source

A Priori Error Estimate of Deep Mixed Residual Method for Elliptic PDEs

Journal of Scientific Computing
In this work, we derive a priori error estimate of the mixed residual method when solving some elliptic PDEs. Our work is the first theoretical study of this method. We prove that the neural network solutions will converge if we increase the training samples and network size without any constraint on the ratio of training samples to the network size ...
Lingfeng Li, Xue-Cheng Tai, Jiang Yang, Quanhui Zhu   +3 more
openaire   +2 more sources

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Adaptive ACMS: A robust localized Approximated Component Mode Synthesis Method

, 2017
We consider finite element methods of multiscale type to approximate solutions for two-dimensional symmetric elliptic partial differential equations with heterogeneous $L^\infty$ coefficients.
Madureira, Alexandre L., Sarkis, Marcus
core  

Mapping Charge Interactions in Intrinsically Disordered Proteins

Advanced Science, EarlyView.
This study presents analytical models to predict intrachain distances in intrinsically disordered proteins (IDPs), accounting for charge patterning, salt concentration, and electrostatic effects. Validated against single‐molecule FRET data, a minimal‐parameter polymer model is identified that captures key interactions and chain dimensions. These models
Michael Phillips, Andrea Holla, Magdalena Wojtas, Aritra Chowdhury, Andrea Sottini, Sebastian L. B. König, Natalie Mutter, Nick Lamb, Jonathan Huihui, Monika Lopko, Andrea Soranno, Daniel Nettels, Andrzej Ożyhar, Benjamin Schuler, Kingshuk Ghosh   +14 more
wiley   +1 more source