Results 211 to 220 of about 471,184 (284)

Ethical clinical trial design and differences in treatment effects. [PDF]

Bull World Health Organ
Lewis RJ, Viele K, Ndomondo-Sigonda M, Sow S, Temfack E, Strub-Wourgaft N.   +5 more
europepmc   +1 more source

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

Prediction of Vancomycin Area Under the Curve With Trough Concentrations Only: Performance Evaluation of Pediatric Population Pharmacokinetic Models. [PDF]

J Infect Dis
Schouwenburg S, Preijers T, Flint RB, Wildschut ED, Koch BCP, de Winter BCM, Abdulla A.   +6 more
europepmc   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, EarlyView.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

Saving the Planet, Saving the Team, and Shouting Down the Messenger: The Relationships Among Narcissism Subtypes and Misreporting of Emissions

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines how three subtypes of narcissism—communal, antagonistic, and collective—relate to sustainability team members' willingness to misreport greenhouse gas (GHG) emissions. Using survey‐based online experiments with experienced professionals from the United States and United Kingdom, we assess whether narcissistic traits predict
Eric N. Johnson, Matthias Sohn
wiley   +1 more source

Using multi-satellite observations to constrain ammonia emissions and unlock their potential over open water. [PDF]

Sci Rep
Momeni M, Kashfi Yeganeh A, Zanganeh Kia H, Ghahremanloo M, Mousavinezhad S, De Guzman HJ, Shephard MW, Jacobson MZ, Choi Y.   +8 more
europepmc   +1 more source

The Role of Social Media in Exposing Greenwashing: Consumer Sentiments and Discussions

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines consumer responses to greenwashing on social media, with a focus on X (formerly Twitter), where exaggerated or deceptive environmental claims are subject to heightened public scrutiny. As sustainability becomes a pressing concern, consumers are increasingly holding companies accountable for their environmental messaging ...
Mitra Salimi, Francesco Tuscolano, Outi Niininen, Outi Uusitalo   +3 more
wiley   +1 more source

Online Estimation of Manipulator Dynamics for Computed Torque Control of Robotic Systems. [PDF]

Sensors (Basel)
Kallel H, Iqbal K.
europepmc   +1 more source

Boards of Directors That Transform: A Study on How Specific Architectural Components Drive ESG Performance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study explores the potential influence of key components of the board of directors' architecture on ESG outcomes. Specifically, we focus on the effects of demographic components (gender and cultural diversity), structural and compositional factors (size, CEO‐Chair separation, and the presence of independent/non‐executive directors), and ...
Jorge Ochaita‐Gonzalez, Jose Angel Zuñiga‐Vicente, Guus Hendriks, Diana Benito‐Osorio   +3 more
wiley   +1 more source