Results 171 to 180 of about 25,939 (216)

A SNP-based capture and clustering workflow to assess donor-derived cell-free DNA in transplantation. [PDF]

PLoS One
Mitsunaga S, Yamada Y, Nguyen PT, Fujito N, Nakaoka H, Aoyama H, Kitamura H, Saigo K, Inoue I, Fujino A, Shinoda M, Fukuda K, Kitagawa Y.   +12 more
europepmc   +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

Brain Pathology, EarlyView.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios, Juan Romero, María de los Ángeles Ramírez‐González, Beatriz Herranz, Alicia Avis‐Bodas, Juliana Manosalva, Diego Megías, Ana Ramos, Juan Manuel Sepúlveda‐Sánchez, Ricardo Gargini, Berta Segura‐Collar, Gabriel Velilla, Bárbara Meléndez, Pedro González, Luis Jiménez‐Roldán, Guillermo García‐Posadas, Aurelio Hernández‐Laín, Ángel Pérez‐Núñez, Pilar Sánchez‐Gómez   +18 more
wiley   +1 more source

Spatio-temporal dynamics of Hendra virus in Australia reveal stable maintenance of diverse viral clades among Pteropus bats. [PDF]

Nat Microbiol
Yinda CK, Eden JS, Prates ET, Vlot A, van Tol S, Anzick SL, Wang J, Halpin K, Borremans B, Lunn TJ, Barbian K, Bulloch B, Greene B, Meade-White K, Bushmaker T, Falvo CA, Crowley DE, Jones-Slobodian DN, Shah M, Pavicic M, Carr W, Martens C, Jacobson D, Plowright RK, Peel AJ, Munster VJ.   +25 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Association between SLCO1B1, apolipoprotein E and ABCG2 genes and lipid response to rosuvastatin: a meta-analysis. [PDF]

Pharmacogenet Genomics
Li J, Deng Y, Lai Y, Li L, Yu L, Li H, Yin Z, Liu L.   +7 more
europepmc   +1 more source

Survey on differential estimators for 3d point clouds

Computer Graphics Forum, EarlyView.
Abstract Recent advancements in 3D scanning technologies, including LiDAR and photogrammetry, have enabled the precise digital replication of real‐world objects. These methods are widely used in fields such as GIS, robotics, and cultural heritage. However, the point clouds generated by such scans are often noisy and unstructured, posing challenges for ...
Léo Arnal–Anger, Thibault Lejemble, David Coeurjolly, Loïc Barthe, Nicolas Mellado   +4 more
wiley   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications. [PDF]

Adv Sci (Weinh)
Sun Y, Li Y, Temur B, Lin Y, Liu Y, Yi L, Sun Z, Zhang G, Li J, Guo Y, Li L, Cai J, Tian W, Meng G, Jiang L, Fang M, Ding F, Zhou X, Tu C, He B.   +19 more
europepmc   +1 more source

Mandibular Overdentures on Four Immediately Loaded Mini‐Implants Versus Two‐Delayed Loaded Regular Implants: 1‐Year, Two‐Center RCT on Patient‐Reported Outcomes

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objective This one‐year randomized clinical trial compared the effects of mandibular implant‐overdentures (IODs) on two two‐piece regular‐neck tissue‐level implants (Group A) or on four mini‐implants (Group B) with different loading protocols in edentulous patients concerning dental Patient‐Reported Outcomes (dPROs).
Martin Schimmel, Cláudio Rodrigues Leles, Nicole Schenk, Simone F. M. Janner, Beat Wallkamm, Valérie G. A. Suter, Samir Abou‐Ayash, Clemens Raabe   +7 more
wiley   +1 more source

Whole Genome Sequencing, Comparative Genome Analysis, and Biotechnological Potential of <i>Emericellopsis alkalina</i> and <i>E. fimetaria</i> (<i>Bionectriaceae</i>, <i>Ascomycota</i>) from the Sediment of Alkaline, Saline Lakes. [PDF]

J Fungi (Basel)
Sokolov VV, Malysheva KV, Bilanenko EN, Markelova NN, Kolpakova OA, Georgieva ML, Sadykova VS.   +6 more
europepmc   +1 more source

Discovery of a cryptic aminoacidic triad involved in the temperature adaptation of GH1 enzymes

The FEBS Journal, EarlyView.
Cold‐active enzymes retain high catalytic activity at low temperatures but are characterized by thermal instability, a behavior not fully understood. Comparison between a cold‐active GH1 and its mesophilic counterparts highlights the role of a three‐residue motif (W‐M‐F) in conferring structural stability to a mesophilic GH1.
Stefania Digiovanni, Gabriel Oanca, Marco Orlando, Marina Lotti, Johan Åqvist, Marco Mangiagalli   +5 more
wiley   +1 more source