Frequency of single nucleotide polymorphisms in NOD1 gene of ulcerative colitis patients: a case-control study in the Indian population. [PDF]
BMC Med Genet, 2009 Background Epidemiological studies have provided enough evidence that genetic factors have an important role in determining susceptibility to IBD. The most significant finding in the IBD research has been identification of mutations in the gene that ...
Verma R, Ahuja V, Paul J.
europepmc +4 more sources
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. [PDF]
Nat Commun, 2016 Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized.
Robinson JE +49 more
europepmc +3 more sources
Citrullinated α-enolase is an effective target for anti-cancer immunity. [PDF]
Oncoimmunology, 2018 Targeting post-translationally modified epitopes may provide a new strategy for generating tumor specific immune responses. Citrullination is the post-translational modification of arginine to citrulline catalyzed by peptidylarginine deaminase (PAD ...
Cook K +8 more
europepmc +4 more sources
Source Attribution of Human Campylobacteriosis Using Whole-Genome Sequencing Data and Network Analysis [PDF]
, 2022 Campylobacter spp. are a leading and increasing cause of gastrointestinal infections world-wide. Source attribution, which apportions human infection cases to different animal species and food reservoirs, has been instrumental in control-and evidence ...
Hald T. +5 more
core +1 more source
p140Cap regulates the composition and localization of the NMDAR complex in synaptic lipid rafts [PDF]
, 2022 The NMDARs are key players in both physiological and pathologic synaptic plasticity because of their involvement in many aspects of neuronal transmission as well as learning and memory.
Alfieri, Annalisa +17 more
core +2 more sources
Essai d'analyses quantitative, qualitative et biogéographique de la flore fu Bou-Naceur (Moyen-Atlas oriental, Maroc) [PDF]
, 2002 Essai d'analyses quantitative, qualitative et biogéographique de la flore du Bou-Naceur (Moyen-Atlas oriental, Maroc). En l'absence d'étude exhaustive sur le Moyen-Atlas oriental, la flore de cette région est restée assez mal connue par rapport au reste ...
Rahou, Abdelilah
core +4 more sources
JRAB/MICAL-L2 undergoes liquid–liquid phase separation to form tubular recycling endosomes [PDF]
, 2022 Elongated tubular endosomes play essential roles in diverse cellular functions. Multiple molecules have been implicated in tubulation of recycling endosomes, but the mechanism of endosomal tubule biogenesis has remained unclear.
Hara, Yusuke +9 more
core
Identification of Molecular Determinants from Moloney Leukemia Virus 10 Homolog (MOV10) Protein for Virion Packaging and Anti-HIV-1 Activity [PDF]
, 2011 Background: MOV10 inhibits HIV-1 replication after being packaged. Results: A Gag binding plus all but one of seven helicase domains are required for MOV10 packaging. Nearly all residues are required for anti-HIV-1 activity.
Abudu, Aierken +5 more
core +2 more sources
Regulated by the interplay of multiple CLASP domains, the localization of the TOGL2 domain to microtubules drives spindle formation in Saccharomyces cerevisiae [PDF]
, 2014 The kinetochore (KT) is a complex structure that enables attachment of chromosomes to spindle microtubules (MTs). Several MT associated proteins (MAPs) contribute to the KT-MT interface and regulate the dynamics of kinetochore microtubules (kMTs).
Schmeiser, Verena
core +1 more source
Multiple Genetic Variants in Telomere Pathway Genes and Breast Cancer Risk [PDF]
, 2010 To explore the etiologic role of genetic variants in telomere pathway genes and breast cancer ...
Bradshaw, Patrick T. +8 more
core +2 more sources