Results 181 to 190 of about 186,391 (248)

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

(AAA)

针刺研究, 1997
韩济生
doaj   +2 more sources

Integrative cross-tissue transcriptome-wide association and metabolomic analysis reveals novel genetic risk loci for aortic aneurysm. [PDF]

Front Nutr
Wang H, Cheng J, Yao J, Jin W, Li W.
europepmc   +1 more source

Multivalent RNA‐Cleaving Agents on a Cubic Octameric Silsesquioxane Core

Chemistry – A European Journal, EarlyView.
RNA‐cleaving agents on a cubic octameric silsesquioxane core were synthesized and characterized. Several catalytic systems of these structures were screened using hexaribonucleotide models. The best systems were then further used to study their catalytic efficiency in cleaving a HER2 mRNA model sequence. The induced cleavage sites were also determined.
Hanni Haapsaari, Iris Tuomi, Pasi Virta
wiley   +1 more source

Clinical features of Q fever vertebral osteomyelitis: case reports and literature review. [PDF]

Front Med (Lausanne)
Zhang T, Gao HL, Liu H, Li SK.
europepmc   +1 more source

Foldamers With Two Distinct Helical Motifs Controlled by Solvent

Chemistry – A European Journal, EarlyView.
Alternating o‐phenylene and 2,3‐pyrazinylene oligomers were synthesized and their conformational behavior studied by NMR spectroscopy, x‐ray crystallography, and DFT calculations. They fold into well‐defined helices, but, remarkably, the folding motif depends on solvent: a compact helix in chloroform, but a much longer extended helix in acetone ...
Yinhui Liao, Vipul Batra, Govinda Prasad Devkota, Annabelle Ryu, Henry S. Oliver, David L. Tierney, C. Scott Hartley   +6 more
wiley   +1 more source

Centralized Digital Surveillance for Abdominal Aortic Aneurysm Detection, Longitudinal Tracking, and Management Within an Integrated Health System: Retrospective Cohort Study. [PDF]

JMIR AI
Ryer EJ, Salzler GG, Goldfarb M, Lewis AJ, Mehta YB, Dinsmore IR, Mirshahi T, Mitchell EG, DeLong G, Elmore JR.   +9 more
europepmc   +1 more source

Design of Solar Energy Harvesting Reactor From 2D to 3D Structures for Solar Thermal Conversion

Carbon Innovation, EarlyView.
ABSTRACT Solar energy utilisation is pivotal for advancing sustainable and renewable energy solutions, yet the rational design of high‐efficiency photothermal conversion devices remains a critical challenge. This paper systematically examines the evolution of photothermal reactor architectures from two‐dimensional (2D) to 3D structures, emphasising ...
Haozhe Zhuang, Runsen Wang, Yuxuan Meng, Yuejun Chen, Sanli Tang, Yuefei Ruan, Vellaisamy A. L. Roy, Meng Lin, Xianguang Meng   +8 more
wiley   +1 more source

Association of infrarenal aortic diameter in siblings within the Stockholm abdominal aortic aneurysm screening programme. [PDF]

Br J Surg
Siika A, Hultgren R, Brinck J, Andersson DP.   +3 more
europepmc   +1 more source

New Insights Into the Three‐Dimensional Mechanics of the Flagellar Beat Cycle

Cytoskeleton, EarlyView.
ABSTRACT Advances in imaging at the molecular scale have provided greater detail concerning the three‐dimensional structure of the ciliary/flagellar axoneme. Additionally, it has recently been confirmed that electrostatic forces regulate the dynein‐tubulin interaction at the microtubule binding domain (MTBD) of dynein, and at the junction of the nexin ...
Charles B. Lindemann
wiley   +1 more source