Results 81 to 90 of about 186,391 (248)

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

Structural and biochemical studies of MCM proteins [PDF]

, 2010
The eukaryotic MCM2-7 replicative helicase is a hetero-complex composed by 6 homologues belonging to the AAA+ ATPase superfamily. These proteins form a ring-like structure which is essential for the initiation and the progression of the replication fork.
Medagli, Barbara
core   +1 more source

Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundAbdominal aortic aneurysm (AAA) is a potentially life‐threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions.
Aya Furusho, Hiroki Aoki, Satoko Ohno‐Urabe, Michihide Nishihara, Saki Hirakata, Norifumi Nishida, Sohei Ito, Makiko Hayashi, Tsutomu Imaizumi, Shinichi Hiromatsu, Hidetoshi Akashi, Hiroyuki Tanaka, Yoshihiro Fukumoto   +12 more
doaj   +1 more source

MMP expression in AAA.

, 2014
(A)Top left) In situ zymography shows an increase in gelatin degrading enzymes (MMPs) in large AAA versus control (data for small AAA was similar; data not shown).
Sam Nwosu (513433), Prudhvidhar R. Perati (513434), Hagai Tavori (513435), Sergio Fazio (513438), David Airey (513432), MacRae F. Linton (5657587), Michael F. Hill (380769), Valentina Kon (513437), Uchechukwu K. Sampson (513439), Petra A. Prins (513431)   +9 more
core   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

The PERMIS X.509 Based Privilege Management Infrastructure [PDF]

, 2002
This document describes the PERMIS X.509 Based Privilege Management Infrastructure, which is a trust management system as described in RFC 2704 [2]. The PERMIS Infrastructure is compared with the AAA Authorisation Framework described in RFC 2904 [4], and
Chadwick, David W.
core  

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm

Acta Pharmaceutica Sinica B, 2015
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disorder with high mortality. Accumulating evidence shows that toll-like receptor 2 (TLR2) plays a critical role in the regulation of wound-repairing process after tissue injury.
Huimin Yan, Bing Cui, Xiaowei Zhang, Xiaoming Fu, Jun Yan, Xiaoxing Wang, Xiaoxi Lv, Zhong Chen, Zhuowei Hu   +8 more
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Cost-effectiveness of the National Health Service Abdominal Aortic Aneurysm Screening Programme in England. [PDF]

, 2014
BACKGROUND: Implementation of the National Health Service abdominal aortic aneurysm (AAA) screening programme (NAAASP) for men aged 65 years began in England in 2009.
Thompson, SG, Glover, MJ, Kim, LG, Buxton, MJ, Sweeting, MJ, Buxton, M. J., Kim, L. G., Glover, M. J., Sweeting, M. J., Thompson, S. G.   +9 more
core   +1 more source