Results 61 to 70 of about 2,708 (258)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Open pit limit optimization considering the pumped storage benefit after mine closure: a case study

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Repurposing a closed mine as lower reservoir is a cost-effective way for the construction of pumped storage hydropower (PSH) plant. This method can eliminate the expenses of mine reclamation, reservoir construction, and land acquisition, resulting in ...
Feiyue Liu, Ke Yang, Tianhong Yang, Wenxue Deng, Hua Li, Lingyue Yang   +5 more
doaj   +1 more source

Investigation of Theoretical Models, Pumping-Recharge Well Arrangements and System Performance of Abandoned Mine Water Source Heat Pump

Energy and Built Environment
Abandoned mines are rich in geothermal resources. In this article, the feasibility of applying a water resource heating system in abandoned mines is explored, adopting mine water in the extraction zone as the research object.
Zhiqiang Zhang, Wenchao Zu, Wenke Zhang, Kexun Wang, Xueqing Ma, Ping Cui   +5 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Effect of heavy metal contamination on the DNA Mutation on Nepenthes plant from abandoned mine [PDF]

, 2016
Objective: Heavy metal contamination on water, soil, crops and including to the other living organisms, including their effects on DNA mutation in abandoned mine is highlighted in this study Methodology: In this study, 6 toxic metals, Zn, Pb, Fe, Cd, Cr ...
Wong, Nyet Kui, Carolyn Melissa Payus, Tan, Siak Ying   +2 more
core   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Understanding exposure risk using soil testing and GIS around an abandoned asbestos mine

Annals of Global Health
Background: Abandoned asbestos mines are a potential source of environmental contamination and exposure for nearby residents. The asbestos exposure risk may persist even after the cessation of mining activity if the mine is not properly closed.
Abhijeet V. Jadhav, Nilesh Gawde, Ramesh Veerappan, Yeyong Choi, Arthur L. Frank   +4 more
doaj   +1 more source

The rise of the mine water level in the area of the former Kohinoor II mine and the influence on the surrounding aquifer systems of abandoned mines in the central part of the North Bohemian Brown Coal Basin

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2011
The aim of this article is to evaluate the process of terminating the mine water pumping after the liquidation of the Kohinoor II coal mine, situated in the central part of the North Bohemian Brown Coal Basin (NBB) and the subsequent resumption of ...
Milan Mikoláš, Jiří Varady, Jaroslav Bažant, František Žoček   +3 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Development status and progress of pumped storage in underground space of closed/abandoned mines

Meitan xuebao
Innovative approaches to the development of clean energy are seen as a significant driving force for achieving China’s “dual carbon” goals. To address the challenge of unstable electricity supply from large-scale renewable energy, the construction and ...
Zhijie WEN, Pengfei JIANG, Zhenqi SONG, Liping LI, Yujing JIANG, Tongkai LIANG   +5 more
doaj   +1 more source