Results 21 to 30 of about 47,094 (264)

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters   +17 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Neonatal Abandonment and Hydrocephalus in Antillean Manatees (Trichechus manatus manatus): Is There a Causal Relationship?

open access: yesAnimals
Manatees are semi-social animals, with the mother–calf relationship being considered long-lasting for the species. However, some events lead to the separation of this pair.
Tiago F. S. Santos   +13 more
doaj   +1 more source

Adoption and Abandonment of Precision Soil Sampling in Cotton Production

open access: yesJournal of Agricultural and Resource Economics, 2008
Adoption of precision agriculture technology has arrived considerable attention, but abandonment has received little. This paper identified factors motivating adoption and abandonment of precision soils sampling in cotton.
Jonathan C. Walton   +9 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Sustainable places in urban settings: abandonments and returning at the time of Agenda 2030

open access: yesGeography Notebooks, 2018
If we consider the theme of abandoned places on the one hand and their rebirth on the other one soon realizes how this issue must necessarily be traced back to the great question of sustainability, which goes beyond the borders of States, uniting all the
Alice Giulia Dal Borgo   +1 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Soil and Vegetation Characteristics of Grassland Have a Greater Influence on the Abundance and Diversity of Earthworms than the Mowing Intensity in a Managed Nature Reserve

open access: yesLand
Effects of mowing on vegetation parameters have been well studied. However, less is known about mowing effects on soil fauna and if soil properties alter this.
Günther Kerschbaumer   +3 more
doaj   +1 more source

Psychological Correlates of Attitudes toward Pet Relinquishment and of Actual Pet Relinquishment: The Role of Pragmatism and Obligation

open access: yesAnimals, 2019
Understanding pet relinquishment is essential to inform interventions and assess their impact. In a cross-sectional study, we explored how attitudes of lack of obligation and pragmatism toward pet relinquishment correlated with, and differed according to,
Rita Jacobetty   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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