Results 71 to 80 of about 47,094 (264)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Abandoned

, 2020
This music score was submitted for the Kaleidoscope 2020 Call for Scores, an open access collaboration with the UCLA Music Library.
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Diversity of the Soil Bacterial Community of Abandoned Jujube Land in the Loess Area of Northern Shaanxi in Different Years

Diversity
This research aimed to study changes in the diversity of the soil bacterial community in a jujube forest with different years of abandonment. To this end, we took the mountain jujube forest with different abandoned years (1 a, 3 a, 6a and 20 a) in the ...
Ning Ai, Menghuan Zou, Xuejiao Yu, Jie Gao   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Migration Architecture and Its Impact on the Rural Territory in Saraguro: Consequences of New Construction in the Quisquinchir Community

Buildings
The indigenous community of Quisquinchir, in Saraguro (Loja, Ecuador), is facing a process of transformation of the rural Andean landscape associated with internal and external migration, as well as the influence of foreign architectural models.
Karina Monteros Cueva, Jessica Andrea Ordoñez Cuenca   +1 more
doaj   +1 more source

Traditional agricultural landscape and their management in less favoured areas in Slovakia

Ekológia (Bratislava), 2016
Traditional agricultural landscapes are a mosaic of small-scale arable fields and permanent agricultural cultivations such as grasslands, vineyards and high-trunk orchards.
Špulerová Jana, Drábová Monika, Lieskovský Juraj   +2 more
doaj   +1 more source

Soil Heterotrophic Respiration Potential and Maximum Respiration Rate of Differently Managed Meadows

Soil and Water Research, 2006
In this study were compared heterotrophic respiratory potential (VDS/VMAX) expressing an increase in C mineralisation rate after drying and re-wetting the soil to 60% soil water content (v/w)(VDS) in relation to maximum respiration rate (VMAX) after ...
Pavel Formánek, Lukáš Kisza, Valerie Vranová   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source