Results 91 to 100 of about 138,427 (307)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Abcès prostatique à staphylococcus Aureus: A propos d’un cas clinique

African Journal of Urology, 2018
Résumé: L’abcès prostatique est causé généralement par les entérobactéries rarement par le staphylococcus aureus. Sa mortalité et morbidité ont baissé depuis l’introduction des antibiotiques à large spectre. Souvent les signes sont non spécifiques.
A. Saouli, O. Yddoussalah, A. Janane, T. Karmouni, M. Alami, A. Ameur, K. El Khader, A. Koutani, A. Iben Attya Andaloussi   +8 more
doaj   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Abcès pottique intra médullaire: à propos d’un cas

The Pan African Medical Journal, 2019
La tuberculose du système nerveux central est une affection rare. Elle se présente sous plusieurs formes mais l'association d'un abcès intra médullaire et un pott multifocal est exceptionnelle.
Haboubacar Chaibou Sode, Assoumane Ibrahim, Hounkpatin Seton Stachys Beranger, Nikiema Habi Alizéta Soong-Meenga, Kelani Aminath, Sanoussi Samuila   +5 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Les Abcès de Cornée à l’Hôpital National de Niamey : Fréquence, Présentation Clinique et Pronostic

Health Research in Africa
RÉSUMÉ Introduction. Les abcès de cornée sont des affections graves qui constituent une urgence ophtalmologique et une des principales causes de cécité cornéenne. Non traités rapidement, ils peuvent entraîner des complications sévères.
Dan Jouma Maman Lawali, Abba kaka HY, Roufaye L, Mamadou IC, Amoumoune GS, Amza A   +5 more
doaj   +1 more source

Etude épidémiologiques et histopathologique de la gale sarcotique et de la teigne chez le dromadaire dans le Sud marocain [PDF]

, 2009
Une étude a été menée entre avril et mai 2009 aux abattoirs de trois villes du Sud marocain, dans le but de collecter des données épidémiologiques sur la gale et la teigne du dromadaire et de réaliser des prélèvements cutanés sur des animaux malades ...
Driot, Caroline
core  

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Adénome mucineux de l'appendice vermiculaire : diagnostic différentiel d’un abcès appendiculaire [PDF]

, 2015
HM Raharimampionona, AMCR Randriamalala, MOJ Harioly Nirina, SSEN Rabesalama   +3 more
openalex   +1 more source