Results 131 to 140 of about 11,287,900 (292)
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
Advanced Science, EarlyView.This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu +7 more
wiley +1 more source
, 2008 A 4-part radio documentary series(4 x 58-53 ) and interactive website about the relationship between Australian popular music and the landscape. Co-produced with Cath Dwyer, Wide Open Road consists of 4 parallel narratives about the development of ...
Morton, T, Dwyer, CM
core
Der katalytische Zyklus der Nukleotid-bindenden Domäne des ABC-Transporters HlyB [PDF]
, 2005 Nucleotide-binding domains (NBDs), roughly 27 kDa in size, are conservative components of the large family of ABC (ATP-binding cassette) transporters, which includes importers, exporters, and receptors.
Zaitseva, Jelena
core
Advanced Science, EarlyView.In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang +11 more
wiley +1 more source
Advanced Science, EarlyView.A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait +7 more
wiley +1 more source
, 1951 Eve Marie Martin and George Martin stand behind the counter in the ABC shop, located at 809 W. 12th St.
Douglass, Neal
core
Fingerprint of the mitochondrial ABC transporter Mdl1p from Saccharomyces cerevisiae [PDF]
, 2006 The multidrug resistance like protein 1 (Mdl1p) belongs to the class of ATP binding cassette (ABC) transporters which comprise a large family of membrane proteins utilising ATP hydrolysis to drive up-hill transport of a wide variety of solutes across ...
Hofacker, Matthias
core
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
estudo sobre viabilidade de implantação do método de Custeio ABC na Empresa Delta [PDF]
, 2011 TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Contabilidade.Esta monografia é o resultado de um estudo sobre a viabilidade de implantação do método de custeio baseado em atividades, também denominado de ABC ...
Schlemper, Rafael Augusto
core
Advanced Science, EarlyView.This work reports on epitaxially grown Hf0.52Zr0.48O2 ferroelectric memristors with high stability (high durability exceeding 108 cycles and a retention time exceeding 104 s for 16 states) and ultra‐low operating energy consumption (∼121 fJ). A memristor array‐based reservoir computing system is constructed and applied for the first time in the field ...
Ying Liu +6 more
wiley +1 more source