Results 131 to 140 of about 95,600 (264)

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Acute brain dysfunction clusters in COVID-19: a pilot machine learning-based analysis of the COVID-D cohort. [PDF]

Intensive Care Med Exp
Romero-García N, Montosa-I-Micó V, Fernández-Narro D, García-Gómez JM, Hurtado L, Passariello E, Taccone FS, Robba C, Raman R, Orun OM, Pandharipande P, Pun BT, Ely EW, Badenes R, Sáez C.   +14 more
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Droperidol for the Management of the Undifferentiated and Agitated Trauma Patient. [PDF]

Emerg Med Australas
Williamson F, Bertenshaw C, Roffey S.
europepmc   +1 more source

Encoding Occupancy in Memory Location for Efficient and Compact High‐Resolution Voxel Structures

Computer Graphics Forum, EarlyView.
We encode information about geometric structure into the pointers of a sparse voxel directed acyclic graph (SVDAG). Each pointer carries information about the structure of the node it points to. Our encoding improves ray tracing performance and reduces model size in memory.
Jaina Modisett, Markus Billeter
wiley   +1 more source

Identification of Transcription Factors Regulating Detoxification Genes <i>CYP9Z140</i>, <i>CYP9AY1</i>, and <i>UGT321AP1</i> Involved in Thiamethoxam Resistance in <i>Leptinotarsa decemlineata</i>. [PDF]

Insects
Tian Z, Liu L, Zhang Q, Zhou D, Fu K, Jia Z, Jiang W.   +6 more
europepmc   +1 more source

Affinification: A Fine Approximation of Deformations

Computer Graphics Forum, EarlyView.
Abstract We introduce affinification, a novel method for accelerating physics‐based animation of elastic solids. During a time‐dependent simulation, our method automatically partitions the space into affine and elastic regions depending on the deformation.
A. Mercier‐Aubin, T. Schneider, P.G. Kry, S. Andrews   +3 more
wiley   +1 more source

To Fix or Not to Fix: Effect of Gastropexy on Esophageal Manometric Values Post Laparoscopic Sleeve Gastrectomy. [PDF]

Obes Surg
Talaat Saber Wassef A, Ali Abd El Kaream Ali M, Mohammed Abd El Fattah Ayad A, K Abosayed A, Yahia Abd El Dayem A, B Hashem M, Omran S, Adel Shalaby Alattar A.   +7 more
europepmc   +1 more source

Insights for conservation from the Ecological Knowledge Games project

Conservation Biology, EarlyView.
Abstract Environmental conservation research requires robust methods for collecting large‐scale behavioral data and engaging diverse stakeholders in decision‐making processes. We (Y.P., A.B.D., and N.B.) created EcoKnowGames (Ecological Knowledge Games), a transdisciplinary project that develops knowledge games for conservation science and data ...
Yuan Pan, A. Bradley Duthie, Isabel Jones, Daksha Patel, Nils Bunnefeld   +4 more
wiley   +1 more source

Correction: Coriander (Coriandrum sativum L.) essential oil and oil-loaded nano-formulations as an anti-aging potentiality via TGFβ/SMAD pathway. [PDF]

Sci Rep
Salem MA, Manaa EG, Osama N, Aborehab NM, Ragab MF, Haggag YA, Ibrahim MT, Hamdan DI.   +7 more
europepmc   +1 more source