Results 61 to 70 of about 114,860 (321)

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

An optimized retroperitoneal approach for open aortic repair by partially removing the tenth rib without incising the pleura and diaphragm

Journal of Vascular Surgery Cases and Innovative Techniques, 2016
The ninth intercostal thoracoretroperitoneal incision is the most common approach for open repair of suprarenal abdominal aortic aneurysm or abdominal aortic dissection, which necessitates incision of the pleura and diaphragm and may lead to ...
Yuewei Wang, MD, Lijia Cui, MD, Fangda Li, MD, Bao Liu, MD, Changwei Liu, MD, Yuehong Zheng, MD   +5 more
doaj   +1 more source

Fenestrated Endovascular Aneurysm Repair versus Snorkel Endovascular Aneurysm Repair: Competing yet Complementary Strategies. [PDF]

, 2019
Juxtarenal/pararenal aortic aneurysms and type IV thoracoabdominal aneurysms pose particular technical challenges for endovascular repair as they involve the visceral segment in addition to insufficient infrarenal neck for the use of standard ...
Yoon, William J
core   +1 more source

Experience of a tutor centric model for sonography training of emergency department registrars in an Australian urban emergency department 2009–2012 [PDF]

, 2015
Purpose: To assess the impact of a regular sonographer proctored training program for emergency medicine trainees in the use of Emergency Department bedside ultrasound Methods: Emergency Department (ED) Registrars in the Swan District Hospital ED were ...
Fear, Mark, Hird, Kathryn, Sweetman, Greg   +2 more
core   +2 more sources

An Objective and Repeatable Sac Isolation Technique for Comparing Biomechanical Metrics in Abdominal Aortic Aneurysms [PDF]

, 2022
Timothy K. Chung, Pete H. Gueldner, Trevor Kickliter, Nathan L. Liang, David A. Vorp   +4 more
openalex   +1 more source

Targeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization

Advanced Science, EarlyView.
This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.
Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao   +11 more
wiley   +1 more source

Mechanistic and pathological study of the genesis, growth, and rupture of abdominal aortic aneurysms [PDF]

, 2013
Postprint (published ...
Bordone, Maurizio, Loong, T. H., N.Y.Kwee, Eddy, Soudah Prieto, Eduardo, Sriram, N., Tan, C. H., Uei, P   +6 more
core   +3 more sources

Computational fluid dynamicaccuracy in mimicking changes in blood hemodynamics in patients with acute type IIIb aortic dissection treated with TEVAR [PDF]

, 2018
Background: We aimed to verify the accuracy of the Computational Fluid Dynamics (CFD) algorithm for blood flow reconstruction for type IIIb aortic dissection (TBAD) before and after thoracic endovascular aortic repair (TEVAR).
Domenig, Christoph, Huk, Ihor, Nanobachvili, Josif, Neumayer, Christoph, Piechota-Polańczyk, Aleksandra, Polanczyk, Andrzej   +5 more
core   +1 more source

Identification of biomarkers and analysis of infiltrated immune cells in stable and ruptured abdominal aortic aneurysms [PDF]

, 2022
Yubin Chen, Tianyu Ouyang, Cheng Fang, Can-e Tang, Kaibo Lei, Longtan Jiang, Fanyan Luo   +6 more
openalex   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source