Results 81 to 90 of about 45,147 (122)

Statin intensity and postoperative mortality following open repair of intact abdominal aortic aneurysm. [PDF]

, 2018
BackgroundThere is a lack of evidence for the association between intensive statin therapy and outcomes following vascular surgery. The aim of this study was to evaluate the association between perioperative statin intensity and in-hospital mortality ...
Alshaikh, HN, Bohsali, F, Gani, F, Malas, M, Nejim, B   +4 more
core  

The clinical use of platelet transfusions: A systematic literature review and meta‐analysis on behalf of the International Collaboration for Transfusion Medicine Guidelines

Transfusion, EarlyView.
Abstract Background Platelets are frequently transfused, but supply and potential harms highlight the importance of appropriate use. Study Design and Methods Our systematic review (SR) followed a predefined protocol. Eligible studies included SRs, randomized controlled trials (RCTs), and matched cohort observational studies between 1946 and March 2025.
Rachel Jug, Ursula La Rocca, Arwa Z. Al‐Riyami, Aarti Bathla, Ryan A. Metcalf, Sandra K. White, Simon J. Stanworth, Susan Nahirniak   +7 more
wiley   +1 more source

Feasibility of conducting a randomized controlled trial to explore the muscular influence of post‐operative intravenous iron treatment for anaemia after major abdominal surgery

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Iron deficiency anaemia is common in patients recovering from major surgery and is associated with poorer post‐operative outcomes. We designed a randomized controlled trial treating post‐operative anaemia with iron therapy to observe the influence on post‐operative recovery.
Beth MacLean, Robert U. Newton, Jayne Lim, Toby Richards   +3 more
wiley   +1 more source

Acute alterations in blood lactate in the setting of transient stress induced myocardial ischaemia

Experimental Physiology, EarlyView.
Abstract An elevation in resting venous blood lactate ([La−]b) levels in conditions of myocardial hypoperfusion is associated with adverse prognosis and survival. This investigation aimed to assess changes in venous [La−]b levels induced by dobutamine stress in the presence and absence of myocardial ischaemia and adverse outcomes at 1 year.
Jamie M. O'Driscoll, Elliot Smith, Matchel Bibat, Jamie J. Edwards, Claire Compton, Konstantina Kipourou, Damian Coleman, Jonathan Wiles, Eliane Cunliffe, Anna Marciniak, Rajan Sharma   +10 more
wiley   +1 more source

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma

The Journal of Physiology, EarlyView.
Abstract figure legend PANX1 and PANX3 show opposite expression patterns in patient‐derived normal skin and cutaneous squamous cell carcinoma (cSCC) tumours, with PANX1 increased and PANX3 mRNA decreased in cSCC tumours compared to skin. Within the tumour PANX1 localizes to all regions, including tumour nests which house cSCC cancer cells and tumour ...
Brooke L. O'Donnell, Danielle Johnston, Ayushi Bhatt, Zahra Kardan, Dan Stefan, Andrew Bysice, Samar Sayedyahossein, Lina Dagnino, Matthew Cecchini, Sampath Kumar Loganathan, Kathryn Roth, Silvia Penuela   +11 more
wiley   +1 more source

Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms

The Journal of Physiology, EarlyView.
Abstract figure legend Left: Pre‐processing. First, we perform the segmentation of the Computer Tomography angiorgraphy (angio‐CT) scans of a healthy patient, obtaining the surface of a healthy thoracic aorta with a Type III aortic arch. Then, we build nine ideal configurations with Descending Thoracic Aortic Aneurysm (DTAA), varying the aortic arch ...
Francesca Duca, Daniele Bissacco, Luca Crugnola, Chiara Faitini, Maurizio Domanin, Francesco Migliavacca, Santi Trimarchi, Christian Vergara   +7 more
wiley   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, Volume 12, Issue 21, June 5, 2025.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Analysis of Nicotine Toxicity and Mechanisms of Senescence in Nucleus Pulposus Cells Using Network Toxicology and Molecular Docking Technique

JOR SPINE, Volume 8, Issue 2, June 2025.
The current study improves cyber toxicology as a method of evaluating environmental toxicity and molecular biological qualities in addition to clarifying the possible molecular pathways of nicotine‐induced senescence in IVDD. ABSTRACT Aim Through the use of network toxicology, the research sought to determine whether cellular senescence and associated ...
Chen Jiang, Chao Song, Chaoqi Chen, Baoxin Shen, Lei Yang, Chi Zhang, Fei Liu, Xiaofei Wu, Feng Chen   +8 more
wiley   +1 more source

Plasminogen Activator Inhibitor 1 Controls Abdominal Aortic Aneurism Formation via the Modulation of TGF‐β/Smad2/3 Signaling in Mice

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Graphical illustration of the mechanism underlying the acceleration of plasminogen activator inhibitor1 deletion‐mediated abdominal aneurysm formation in mice undergoing calcium chloride2 induction surgery. Genetic intervention targeted toward plasminogen activator inhibitor1 accelerated AAA formation via the modulation of TGF‐β/Smad2/3 signaling in ...
Mantong Zhao, Lina Hu, Zhuo Lin, Xueling Yue, Xintong Zheng, Meiling Piao, Xianglan Jin, Limei Piao, Rihua Cui, Meilan Liu, Xian Wu Cheng   +10 more
wiley   +1 more source

Screening for abdominal aortic aneurysm

Journal of British Surgery, 2001
In spite of increasing number of elective resections of abdominal aortic aneurysms (AAA) the mortality or ruptured AAA is increasing. The advantages of elective operations are obvious; the lethality is 2-6% while the lethality of ruptured AAA is 75-95%. However, AAA seldom causes symptoms before rupture.
openaire   +3 more sources