Results 101 to 110 of about 25,133 (198)

Multidisciplinary Approach in Management of Currarino Syndrome in a Female Infant: A Case Report on Rare Congenital Triad and Focused Literature Review

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Currarino Syndrome (CS) should be suspected in infants presenting with persistent constipation and sacral anomalies. Early diagnosis using appropriate imaging and multidisciplinary surgical management is essential to prevent serious complications such as bowel obstruction, infection, and neurological impairment.
Ferdinand Medard Shilikale   +4 more
wiley   +1 more source

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

open access: yesEpilepsia Open, Volume 11, Issue 4, Page 1329-1342, August 2026.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster   +16 more
wiley   +1 more source

Intra‐abdominal pressure and intestinal microbiome are associated with clinical outcomes in sepsis patients receiving early enteral nutrition: A prospective observational study

open access: yesHong Kong Journal of Emergency Medicine, Volume 33, Issue 4, August 2026.
Abstract Introduction Intra‐abdominal pressure (IAP) and gut microbiota have been associated with the prognosis of patients with sepsis receiving early enteral nutrition (EEN). In this study, we investigated this association and its prognostic value. Methods In this prospective observational study, we enrolled patients with sepsis receiving EEN.
Kaihui Zheng   +9 more
wiley   +1 more source

The relationship between central venous pressure, caval–aortic index and inferior vena cava diameter in sepsis

open access: yesHong Kong Journal of Emergency Medicine, Volume 33, Issue 4, August 2026.
Abstract Background Rapid bedside assessment of intravascular volume status is critical during early sepsis management in the emergency department (ED) yet commonly used static parameters such as central venous pressure (CVP) and isolated inferior vena cava (IVC) measurements have limited reliability for predicting fluid responsiveness. Objectives This
Tuba Şafak   +3 more
wiley   +1 more source

Inverse association between obesity and intestinal endometriosis: Findings from a cross‐sectional study

open access: yesInternational Journal of Gynecology &Obstetrics, Volume 174, Issue 2, Page 1044-1049, August 2026.
Abstract Objective This study evaluates the association between obesity and the presence of bowel endometriosis in patients undergoing surgery. Methods A retrospective cross‐sectional observational study was conducted with patients treated between September 2023 and December 2024, at a specialized endometriosis outpatient clinic of a tertiary hospital ...
Tereza Carolina Fonseca Corrêa   +1 more
wiley   +1 more source

GLIM criteria for the diagnosis of malnutrition in patients with cirrhosis: A narrative review

open access: yesJournal of Parenteral and Enteral Nutrition, Volume 50, Issue 6, Page 781-793, August 2026.
Abstract Background This narrative review aims to describe and discuss the validity of the Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with cirrhosis. Methods The literature search was performed in PubMed and EMBASE between May and August 2024 and updated in January 2025, including original studies published in English in ...
Bárbara Chaves Santos   +6 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang   +9 more
wiley   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

open access: yesPhytotherapy Research, Volume 40, Issue 8, Page 5071-5089, August 2026.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang   +7 more
wiley   +1 more source

Endothelial AGGF1 Deficiency Causes Mitochondrial Dysfunction and Contributes to Age‐Elevated Blood Pressure

open access: yesAging Cell, Volume 25, Issue 8, August 2026.
Endothelial AGGF1 deficiency contributes to early vascular aging and age‐elevated blood pressure via inhibiting the SESN2/p‐eNOS pathway. Age‐dependent AGGF1 attenuation reduces its binding to the SESN2 promoter. SESN2 downregulation induces mitochondrial respiratory dysfunction and elevated mitochondrial ROS, thereby reducing eNOS phosphorylation ...
Weixin Lv   +16 more
wiley   +1 more source

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