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Antibiotics for Abdominal Sepsis

New England Journal of Medicine, 2015
Major milestones in surgery have included safe sutures to promote tissue integrity, cautery to minimize bleeding, the use of anesthesia to avoid pain, and antisepsis to prevent operative contamination. In the antibiotic era, surgical procedures for source control in abdominal sepsis have been complemented with drugs targeting persistent organisms after
Richard P, Wenzel, Michael B, Edmond
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Abdominal Sepsis

Current Infectious Disease Reports, 2016
Abdominal infections are an important challenge for the intensive care physician. In an era of increasing antimicrobial resistance, selecting the appropriate regimen is important and, with new drugs coming to the market, correct use is important more than ever before and abdominal infections are an excellent target for antimicrobial stewardship ...
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Intra-abdominal sepsis

Medical Clinics of North America, 1995
This article addresses controversial issues in the field of intra-abdominal sepsis with particular attention to major changes in management that have evolved during the past decade. In the area of diagnostics, scanning techniques have revolutionized the ability to detect loculated collections, although many of these techniques are of limited value in ...
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Immunopathogenesis of abdominal sepsis

Langenbeck's Archives of Surgery, 2013
Sepsis is an unsolved problem worldwide, with a 30-50 % mortality rate. The recent failures of anti-TLR4, recombinant activated protein C, and anti-TNF in clinical trials indicate a need to rethink our current understanding of sepsis’s pathophysiology. While the initial immune response is crucial for effective clearance of invading pathogens, an overly
Georg F, Weber, Filip K, Swirski
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Management of abdominal sepsis

Langenbeck's Archives of Surgery, 1998
Today the management of the different forms of peritonitis is generally standardised. The classification of primary and secondary peritonitis is well accepted. From a pathophysiological point of view, postoperative and post-traumatic peritonitis should be considered as independent entities.
D, Berger, K, Buttenschoen
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Intra-abdominal sepsis

Surgery (Oxford), 2015
Abstract Intra-abdominal sepsis is frequently seen and dealt with by surgeons. It presents as a spectrum of conditions ranging from uncomplicated localized infection through to severe systemic sepsis with generalized peritoneal infection. Complicated sepsis is frequently associated with a systemic inflammatory response, which can rapidly progress ...
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Abdominal sepsis and oxidative stress

Khirurgiya. Zhurnal im. N.I. Pirogova, 2015
Oxidative stress deserves special attention in the pathogenesis of sepsis.The study included 96 patients with abdominal sepsis caused by advanced suppurative peritonitis and destructive pancreatitis. All patients were divided into 3 groups depending on the severity of sepsis.
I N, Pasechnik   +6 more
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Intra-abdominal Sepsis

2010
Postoperative infection has surpassed hemorrhage as the leading cause of mortality among surgical patients. Despite advances in diagnostic modalities, antibiotic therapy, and critical care medicine, mortality remains high. Intra-abdominal infection is defined as an inflammatory response of the peritoneum to microorganisms and their toxins, which ...
Marc E. Brozovich, Peter W. Marcello
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