Results 151 to 160 of about 454,061 (340)
Liver fibrosis is a growing global health burden with no specific treatment. HSC activation is the predominant driver of liver fibrogenesis and the current focus in antifibrotic drug discovery. This study identifies autocrine GDF10 activates BMPR2/ALK3‐SMAD1/5/8‐SMAD7 pathway to counteract the TGF‐β‐SMAD2/3 pathway in HSCs, thereby inhibiting HSC ...
Yinliang Zhang+16 more
wiley +1 more source
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi+11 more
wiley +1 more source
A zwitterionic asymmetric patch is developed via self‐induced phase separation. The cationic layer exhibits anti‐bacterial efficacy and releases pro‐healing factor, while the zwitterionic hydrogel prevents contamination and visceral adhesion. The strong mechanical interlocking of two layers leads to a high and stable burst pressure tolerance.
Zeping Huang+11 more
wiley +1 more source
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng+10 more
wiley +1 more source
A Clinical Lecture on Recent Advances in Abdominal Surgery [PDF]
C. G. Wheelhouse
openalex +1 more source
The aldehyde‐ and catechol‐modified starch (ACS) microparticle (MP) is developed by chemical modifications and freeze‐milling after calcium intercalation for highly absorbent and tissue‐adhesive properties. The ACS‐MP can be self‐gelled upon contact with biological fluids and blood on tissue surfaces, rapidly absorbing them and achieving robust wet ...
Soohwan An+7 more
wiley +1 more source