Results 131 to 140 of about 127,194 (308)

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

An operated case of delayed stenosis of the small intestine following blunt abdominal trauma.

, 1995
Kazuki Tamura, Shigehiko Itoh, Daikichi Okada, Shinya Yamaguchi, Tsutomu Tagawa, Masahiro Kobayashi, Hisakuni Ooe   +6 more
openalex   +2 more sources

KLK1 as an Epithelial‐Specific Brake Inhibits Colorectal Tumorigenesis by Suppressing B1R‐Mediated Fibroblast Phenotypic Transition

Advanced Science, EarlyView.
KLK1 downregulation disrupts the intestinal mucosal barrier and impairs kallikrein‐kinin signaling, thereby reducing Lys‐des‐Arg9‐BK production. This enhances B1R activation on ADAMDEC1⁺ fibroblasts, promoting inflammation and extracellular matrix (ECM) remodeling. The resulting iCAFs promote colorectal cancer progression, highlighting a novel KLK1‐B1R
Lisha Zhou, Meijing Wang, Shunji Liu, Limei Gu, Shijia Liu, Qianming Du, Tianyi Zhang, Yinuo Ma, Lixin Zhao, Jiaming Wang, Qiang Xu, Tingsheng Ling, Haibo Cheng, Hongqi Chen, Yang Sun   +14 more
wiley   +1 more source

Splenic Torsion Following Blunt Abdominal Trauma. [PDF]

J Clin Med
Arkuszewski PT, Grochowska A, Jachymczak W, Kłosiński KK.   +3 more
europepmc   +1 more source

Three-dimensional reconstruction by spiral computed tomography to locate aortic tear following blunt abdominal trauma

, 1997
Ataul Qureshi, Nathan Roberts, A.A. Nicholson, B Johnson   +3 more
openalex   +1 more source

The accuracy of abdominal ultrasound in paediatric trauma [PDF]

, 2001
Ross Murphy
openalex   +1 more source

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Systematic review and meta-analysis of emergency ultrasonography for blunt abdominal trauma [PDF]

, 2001
Dirk Stengel, K. Bauwens, Jalid Sehouli, Franz Porzsolt, G. Rademacher, Sven Mutze, Axel Ekkernkamp   +6 more
openalex   +1 more source

Next‐Generation Piezoelectric Materials in Wearable and Implantable Devices for Continuous Physiological Monitoring

Advanced Science, EarlyView.
An analysis of literature trends and a historical overview of organic and inorganic piezoelectric materials, focusing on their structural diversity, functional mechanisms, and inherent characteristics. It then explores cutting‐edge developments in material synthesis, fabrication processes, and performance optimization, highlighting their applicability ...
Bangul Khan, Umay Amara, Bilawal Khan, Wasim Ullah Khan, Rafi u Shan Ahmad, Muhammad Shehzad Khan, Mohamed Elhousseini Hilal, Bee Luan Khoo   +7 more
wiley   +1 more source

Blunt abdominal trauma: a retrospective study on clinical insights and treatment outcomes. [PDF]

J Trauma Inj
Kumar A, Sridhar R, Kumar H, Hakeem S A, Khan AV, Anwer M.   +5 more
europepmc   +1 more source