Results 141 to 150 of about 260,909 (310)

Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

Advanced Science, EarlyView.
Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner   +24 more
wiley   +1 more source

Mesenteric Pseudocyst Following Blunt Abdominal Trauma: Report of a Case and Review of Literature

, 2022
Klaudia Gjinoska, Огнен Костовски, Andrej Nikolovski, Daniela Bajdevska Dukoska, Agron Alimi, Svetozar Antović   +5 more
openalex   +1 more source

Generating Coherent Messages in Real-time Decision Support: Exploiting Discourse Theory for Discourse Practice

, 1997
This paper presents a message planner, TraumaGEN, that draws on rhetorical structure and discourse theory to address the problem of producing integrated messages from individual critiques, each of which is designed to achieve its own communicative goal ...
Carberry, Sandra, Harvey, Terrence
core   +2 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

A Case Report of Missed Diaphragmatic Rapture following Abdominal Blunt Trauma [PDF]

Diaphragm is a skeletal-muscle dome-shaped structure which separates abdominal cavity from thoracic cavity. Diaphragmatic rupture may occur in blunt trauma, penetrating trauma or iatrogenic interventions.
خلقی فرد, مینا, رضازاده, امين, شفائی خانقاه, یوسف, فیضی, ایرج, میرزایی, مینا   +4 more
core  

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Comparative assessment between Clinical and CT scan diagnosis in the treatment of blunt abdominal trauma

, 2020

openalex   +2 more sources

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Patterns and outcomes of abdominal trauma patients Admitted to Trauma Intensive Care Unit.. [PDF]

, 2020
Seham Mohamed
openalex   +1 more source

All‐Hydrogel‐Based Organic Electrochemical Transistors for Implantable Physiological Signal Monitoring

Advanced Science, EarlyView.
All‐hydrogel based n‐type depletion‐mode OECTs is developed using a semiconductor hydrogel formed via ionic‐liquid‐mediated phase separation, combining efficient ion‐electron transport, tissue‐like softness, and long‐term biocompatibility. The device can monitor EOG and ECG on human skin and record real‐time ECG subcutaneously in rats, providing a ...
Qicheng Liang, Yue Wang, Ruizhe Wang, Wanfang Zhang, Runcheng Hao, Yueheng Zhong, Jingling Zhang, Xiang Li, Weichu Chen, Chunyu Fan, Yuwen Zhu, Yu Sun, Hong Jiang, Hengda Sun, Gang Wang   +14 more
wiley   +1 more source