Results 131 to 140 of about 533,468 (290)

Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD

EMBO Molecular Medicine
Altered respiratory barrier integrity and impaired lung regeneration are hallmarks of chronic obstructive pulmonary disease (COPD). To investigate the molecular mechanisms driving the impaired regeneration of alveolar epithelial progenitors in COPD, we ...
Maria Llamazares-Prada, Uwe Schwartz, Darius F Pease, Stephanie T Pohl, Deborah Ackesson, Renjiao Li, Annika Behrendt, Raluca Tamas, Vedrana Stammler, Mandy Richter, Thomas Muley, Michael Scherer, Joschka Hey, Elisa Espinet, Claus P Heußel, Arne Warth, Marc A Schneider, Hauke Winter, Felix JF Herth, Charles D Imbusch, Benedikt Brors, Vladimir Benes, David Wyatt, Tomasz P Jurkowski, Heiko F Stahl, Christoph Plass, Renata Z Jurkowska   +26 more
doaj   +1 more source

Regional Development Agencies and Physical Regeneration: Can RDAs actually deliver the Urban Renaissance? [PDF]

, 2002
This paper reports on the results of recent research examining the scope of current and future Regional Development Agency (RDA) activity to promote physical regeneration.
Greenhalgh, Paul, Shaw, Keith
core  

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

cGAS–STING pathway modulation: A new hope for neural regeneration

Neural Regeneration Research
In recent decades, the limitations of therapeutic interventions have elevated neurological disorders and injuries to a prominent position in academic research.
Jinghan Zhang, Mouyuan Sun, Yaxian Luo, Mikko Petteri Räisänen, Lianjie Peng, Luying Qin, Mengfei Yu, Haifei Shi   +7 more
doaj   +1 more source

Creativity, Urban Regeneration and Sustainability: the Bordeaux case study

, 2012
Creative cities are currently working on how to improve the interaction between regeneration building, economic development and social renewal in order to achieve more comprehensive development of the city (Carta, 2004; Florida, 2005). In recent decades,
Sepe M, Martone A
core  

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source

Regulation of lung progenitor plasticity and repair by fatty acid oxidation

JCI Insight
Idiopathic pulmonary fibrosis (IPF) is an age-related interstitial lung disease, characterized by inadequate alveolar regeneration and ectopic bronchiolization.
Quetzalli D. Angeles-Lopez, Jhonny Rodriguez-Lopez, Paula Agudelo Garcia, Jazmin Calyeca, Diana Álvarez, Marta Bueno, Lan N. Tu, Myriam Salazar-Terreros, Natalia Vanegas-Avendaño, Jordan E. Krull, Aigul Moldobaeva, Srimathi Bogamuwa, Stephanie S. Scott, Victor Peters, Brenda F. Reader, Sruti Shiva, Michael Jurczak, Mahboobe Ghaedi, Qin Ma, Toren Finkel, Mauricio Rojas, Ana L. Mora   +21 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Chemical Strategies for Multistimuli Responsive Dynamic Covalent Materials in Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
Multistimuli responsive dynamic covalent materials integrate reversible chemistry with the complex chemical, mechanical, and biochemical cues of regenerative environments. This review highlights chemical strategies based on orthogonal dynamic bonds, multicomponent networks, and hierarchical architectures to regulate mechanics, degradation, and ...
Saurabh Joshi, Matthew B. Baker, Dominik Schauenburg   +2 more
wiley   +1 more source