Results 211 to 220 of about 243,905 (335)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Visual outcome of a diffractive trifocal intraocular lens in eyes with short axial length. [PDF]

BMC Ophthalmol
Qin R, Liu Y, Shen Z, Liu D, Li Z, Sun Z, Qi H.   +6 more
europepmc   +1 more source

Effects from chronic restraint-induced stress and total body Fe-particle irradiation on the induction of chromosomal aberrations in splenocytes of Trp53-heterozygous mice

, 2018
孝則 勝部, 冰 王, 薫 田中, 康晴 二宮, 博一 平川, 翠華 劉, 耕一 丸山, Guillaume Vares, 強 劉, 徹夫 中島, 亮 藤森, 充 根井, Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi   +22 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Aberration correction expands the treatment envelope for histotripsy in the liver. [PDF]

Phys Med Biol
Yeats E, Lu N, Sukovich J, Xu Z, Hall TL.   +4 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Ultrasound Autofocusing: Common Midpoint Phase Error Optimization via Differentiable Beamforming. [PDF]

IEEE Trans Med Imaging
Simson W, Zhuang L, Frey BN, Sanabria SJ, Dahl JJ, Hyun D.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Effect of Chromatic Aberration on White-Light Contrast Sensitivity With Higher-Order Monochromatic Aberrations Correction in the Human Eye in Screen-Based Vision. [PDF]

Transl Vis Sci Technol
Meng Z, Yang Y, Zhang Z, Jiang W, Yang C, Nie Y, Zhao J, Dai Y.   +7 more
europepmc   +1 more source

Absence of Sister Chromatid Exchange and Chromosome Aberrations in Mice After in vivo Exposure of Centchroman-a New Non-steroidal Oral Contraceptive.

, 1995
Ashok K. Giri, Kaleem Ahmed Khan
openalex   +2 more sources