Results 81 to 90 of about 1,414 (184)
CNS Neuroscience &Therapeutics, Volume 31, Issue 11, November 2025.Jolkinolide B improves ischemia–reperfusion injury by inhibiting the JAK2/STAT3 signaling pathway, regulating the polarization of microglia from the M1 to the M2 phenotype, and suppressing the release of pro‐inflammatory cytokines. ABSTRACT Background Microglia polarization and inflammatory response are closely related to cerebral ischemia–reperfusion ...
Yupeng Guo +5 more
wiley +1 more source
Chemical Constituents with Cytotoxic Activity from Dracocephalum imberbe
ChemistrySelect, Volume 10, Issue 30, August 8, 2025.The isolation, purification, structural determination, and cytotoxic activity studies were carried out on D. imberbe for the first time. The flavonoid glycosides 1–2 demonstrated notable cytotoxic activity selectively against MCF‐7 cells. The major compound 1 is particularly noteworthy for its potential efficacy in treating various cancers such as lung
Seda Kilincarslan +6 more
wiley +1 more source
Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Studies [PDF]
, 2019 [EN] The first semisynthesis and biological profiling of the new abietane diterpenoid (+)-liquiditerpenoic acid A (abietopinoic acid) (7) along with several analogues are reported. The compounds were obtained from readily available methyl dehydroabietate
Bassett, Rachel +8 more
core +2 more sources
Plant Biology, Volume 27, Issue 5, Page 698-709, August 2025.This study reports the discovery and functional characterization of PvKSL1, a previously unrecognized class I diterpene synthase from switchgrass. Abstract The diverse class of plant diterpenoid metabolites serves important functions in mediating growth, chemical defence, and ecological adaptation. In major monocot crops, such as maize (Zea mays), rice
G. Wyatt, P. Zerbe, K. Tiedge
wiley +1 more source
Collective Syntheses of Icetexane Natural Products Based on Biogenetic Hypotheses [PDF]
, 2016 A divergent synthesis of 10 icetexane natural products based on a proposed biogenetic cationic ring expansion of a reduced carnosic acid derivative is described.
Gademann, Karl +2 more
core +2 more sources
Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.Phacidium infestans DSM 5139 was studied for its ability to penetrate pine needles and overcome their inhibitory compounds. Using mass spectrometry and genome mining, we identified the biological and molecular strategies enabling nutrient acquisition and resilience against chemical stress, providing insights into the survival mechanisms of this cold ...
Chahira Zerouki +5 more
wiley +1 more source
MOLECULAR INDICATORS FOR TAXODIUM DUBIUM AS COAL PROGENITOR OF "CHUKUROVO" LIGNITE, BULGARIA [PDF]
, 2004 The coal sediment under study was of Miocene/Pliocene geological age. The petrological data pointed to Tortonian/Sarmatian age, while the paleobotanical ones - to Middle Miocene.
Stefanova, M.
core +1 more source
Diterpenes from Different Fungal Sources and Their 13C-NMR Data [PDF]
, 2018 Diterpenes are one of the classes of natural products with about 7000 structures. The basic skeleton of diterpene contains 20 carbon atoms. Microbes contain a large number of diterpenoid with many oxidized carbons and nitrogen atoms. To date, a number of
Farhat, Fozia +3 more
core +1 more source
Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi - SPECIAL ISSUE "NEW TALENT: EUROPE" [PDF]
, 2016 Derivatives of dehydroabietic acid bearing different amino acids scaffolds have potent antiprotozoal activity against Leishmania donovani and Trypanosoma cruzi, with good to high selectivity, and can therefore be regarded as good models for further ...
Brun, Reto +7 more
core +1 more source
Evolution, biosynthesis and regulation of diterpene resin acids in Norway spruce (Picea abies) specialized defense metabolism [PDF]
, 2021 Multi-step biochemical pathways in plants is a challenging area of trait dissection as plants rapidly evolve novel specialized metabolites, often resulting in genus- or species-specific chemical compounds that are synthesized by unrelated gene families ...
O'Donnell, Andrew
core