Results 111 to 120 of about 27,548 (334)

Between abjection and fetishization. Challenges of writing about emotional othering in Disability Studies

open access: yese-cadernos ces
This paper traces the challenges of writing about an emotional othering of disabled people – between abjection and fetishization. These challenges can firstly be characterized as conceptual challenges. To date, theory-building in Disability Studies about
Yvonne Wechuli
doaj   +1 more source

An ‘axe for the frozen sea’ : Estrin’s magic agential realism, insect thigmotaxis, and the problem with Kafka [PDF]

open access: yes, 2014
This paper seeks to demonstrate how Marc Estrin’s Insect Dreams: the Half Life of Gregor Samsa constitutes the first piece of magic agential realist literature about insects.
Chen, Melvin
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Review: Lesa Lockford (2004). Performing Femininity: Rewriting Gender Identity

open access: yesForum: Qualitative Social Research, 2006
Performing Femininity is composed of a series of performances presented by the author to a varied audience, from customers at a strip club in New Orleans to a university class, in which a feminist history "Spin the Bottle" game was an integral part ...
Mary Gergen
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Mike Kelley and Surrealism: monkeys, frogs, dogs and Mauss [PDF]

open access: yes, 2013
This paper reads the 1980s and 1990s soft toy and sock-monkey installations of multimedia artist Mike Kelley in relation to surrealism. Using Hal Foster’s comments on abject art - of which Kelley is often considered an exponent - I consider the extent ...
Haynes, Doug
core   +1 more source

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