Results 71 to 80 of about 27,548 (334)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Gothic Remembering in Stephen King's "It Grows On You"

Current Objectives of Postgraduate American Studies, 2014
This essay introduces the notion of gothic remembering as a means to conceptualize hauntings in a small-town setting. It emphasizes the breakdown of a normative construction of communal past by foregrounding the focus of remembering on abject images and ...
Thorsten Burkhardt
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Chaos and Order in Nature/Creation: A Reading of Genesis l-2:4a in Dialogue with Science and Philosophy [PDF]

, 2012
With inspiration from post-modern scientific theories (complexity theory, chaos theory, relativity theory, uncertainty theory, no-singularity/boundary theory), and from philosophical understandings of nature (ecstatic naturalism and Taoism), the author ...
Kimm, Jean H.
core   +1 more source

Masculinity, Scatology, Mooning and the Queer/able Art of Gilbert & George: On the Visual Discourse of Male Ejaculation and Anal Penetration [PDF]

, 2011
The aim of this essay is to investigate the intersections between masculinity, shame, art, anality, the abject and embodiment by focusing on a particular period of the British art duo Gilbert & George's work in the 1990s.
CAKIRLAR, C
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Kristevan Abjection in Muriel Spark and Charlotte Perkins Gilman’s Female Narratives

Journal of Literature and Humanities
Viewing linguistic and semiotic processes as constitutive of self, Julia Kristeva emphasizes the role of abjection in the construction of female subjectivity.
Elif Toprak Sakız
doaj   +1 more source

When Bodies Go Digital

Angles, 2016
This article intends to investigate contemporary works of art (“Rain Room”, “On Air”), fiction (David Mitchell, Jeannette Winterson, Thomas Pynchon, Kazuo Ishiguro) and films (The Congress, Black Mirror) together with emerging social practices to charter
Claire Larsonneur
doaj   +1 more source

Howling (and Bleeding) at the Moon: Menstruation, Monstrosity and the Double in the \u3ci\u3eGinger Snaps\u3c/i\u3e Werewolf Trilogy [PDF]

, 2008
In this essay, I explore the radical reframing of the traditional werewolf narrative with respect to the figure of the double and the abject female body in the Ginger Snaps werewolf trilogy. Notable theorists discussed herein include Barbara Creed, Carol
Flaherty, Erin M.
core   +1 more source